製品の概要

  • 製品名Anti-TYK2 antibody
    TYK2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TYK2
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within C terminal amino acids 1021-1070 (HRDLAARNVL LDNDRLVKIG DFGLAKAVPE GHEYYRVRED GDSPVFWYAP) of Human TYK2 (NP_003322).

  • ポジティブ・コントロール
    • COLO205 cell lysate

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab108064 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 134 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 機能Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
  • 組織特異性Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
  • 関連疾患Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
    Contains 1 FERM domain.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
  • ドメインThe FERM domain mediates interaction with JAKMIP1.
  • Information by UniProt
  • 参照データベース
  • 別名
    • JTK 1 antibody
    • JTK1 antibody
    • Non receptor tyrosine protein kinase 2 antibody
    • Non receptor tyrosine protein kinase TYK2 antibody
    • Non-receptor tyrosine-protein kinase TYK2 antibody
    • OTTHUMP00000232745 antibody
    • OTTHUMP00000232746 antibody
    • OTTHUMP00000232748 antibody
    • Protein Tyrosine Kinase 2 antibody
    • TYK 2 antibody
    • Tyk2 antibody
    • TYK2_HUMAN antibody
    • Tyrosine kinase 2 antibody
    see all

Anti-TYK2 antibody 画像

  • Anti-TYK2 antibody (ab108064) at 1 µg/ml + COLO205 cell lysate at 10 µg

    Predicted band size : 134 kDa

Anti-TYK2 antibody (ab108064) 使用論文

ab108064 has not yet been referenced specifically in any publications.

Product Wall

Thank you for providing this information. For the detection of TYK2, I selected the following antibodies : - ab39550 : non-phospho peptide around Tyr 1054. 79% when comparing the region aa 1045-1064 (which is not the exact immunogen seque...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"