製品の概要

  • 製品名Anti-TWEAK antibody
    TWEAK 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to TWEAK
  • アプリケーション適用あり: Neutralising, WB, Indirect ELISA, Sandwich ELISAmore details
  • 種交差性
    交差種: Recombinant Fragment
    交差が予測される動物種: Human
  • 免疫原

    Highly pure (>98%) recombinant Human TWEAK.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab109824 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Neutralising Use a concentration of 0.1 - 0.2 µg/ml. to yield one-half maximal inhibition inhibition [ND50] of the biological activity of Human TWEAK (200 ng/ml)
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 27 kDa. The detection limit for recombinant Human TWEAK is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
Indirect ELISA Use a concentration of 0.5 - 2 µg/ml. ab109824 allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human TWEAK (using 100 µl/well antibody solution).
Sandwich ELISA Use a concentration of 0.5 - 2 µg/ml. Can be paired for Sandwich ELISA with Goat polyclonal to TWEAK (Biotin) (ab83437). ab109824 in conjunction with ab83437 as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human TWEAK (using 100 µl/well antibody solution).

ターゲット情報

  • 機能Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
  • 組織特異性Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
  • 配列類似性Belongs to the tumor necrosis factor family.
  • 翻訳後修飾The soluble form derives from the membrane form by proteolytic processing.
  • 細胞内局在Secreted and Cell membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • APO 3 ligand antibody
    • APO 3L antibody
    • APO3 ligand antibody
    • APO3/DR3 ligand antibody
    • APO3L antibody
    • DR3LG antibody
    • MGC129581 antibody
    • MGC20669 antibody
    • secreted form antibody
    • TNF-related weak inducer of apoptosis antibody
    • TNF12_HUMAN antibody
    • TNFSF 12 antibody
    • Tnfsf12 antibody
    • TNFSF12 protein antibody
    • Tumor necrosis factor (ligand) superfamily member 12 antibody
    • Tumor necrosis factor ligand superfamily member 12 antibody
    • Tumor necrosis factor superfamily member 12 antibody
    • TWEAK antibody
    • UNQ181/PRO207 antibody
    see all

Anti-TWEAK antibody (ab109824) 使用論文

This product has been referenced in:
  • Bover LC  et al. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol 178:8183-94 (2007). Read more (PubMed: 17548657) »

See 1 Publication for this product

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The immunogen sequence for antibody ab108924 is a E.coli expressed recombinant protein with sequence MKGRKTRARR AIAAHYEVHP RPGQDGAQAG VDGTVSGWEE ARINSSSPLR YNRQIGEFIV TRAGLYYLYC QVHFDEGKAV YLKLDLLVDG VLALRCLEEF SAT...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"