製品の概要

  • 製品名
  • 製品の詳細
    Mouse monoclonal to TUBA6
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-450 of Human TUBA6

  • 特記事項

    Abcam is committed to meeting high standards of ethical manufacturing and as such, we will be discontinuing this product, which has been generated by the ascites method, within the next year. We are sorry for any inconvenience this may cause. If you would like help finding an alternative product, please do not hesitate to contact our scientific support team.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度
    Protein G purified
  • ポリ/モノ
    モノクローナル
  • アイソタイプ
    IgG1
  • 軽鎖の種類
    kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab57905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
    • 配列類似性
      Belongs to the tubulin family.
    • 翻訳後修飾
      Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
      Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
      Acetylation of alpha-tubulins at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
    • 細胞内局在
      Cytoplasm > cytoskeleton.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Alpha tubulin 6 antibody
      • Alpha tubulin isotype M alpha 6 antibody
      • Alpha-tubulin 6 antibody
      • bcm948 antibody
      • M[a]6 antibody
      • TBA1C_HUMAN antibody
      • Tuba1c antibody
      • Tubulin alpha 1C chain antibody
      • tubulin alpha 6 antibody
      • Tubulin alpha 6 chain antibody
      • Tubulin alpha-1C chain antibody
      • Tubulin alpha-6 chain antibody
      • tubulin, alpha 1c antibody
      see all

    Anti-TUBA6 antibody 画像



    • Predicted band size : 50 kDa
      TUBA6 antibody (ab57905) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    プロトコール

    Anti-TUBA6 antibody (ab57905) 使用論文

    ab57905 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57905.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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