Anti-TTC3 抗体 (ab80061)
Key features and details
- Rabbit polyclonal to TTC3
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TTC3 antibody -
製品の詳細
Rabbit polyclonal to TTC3 -
由来種
Rabbit -
特異性
Reacts specifically with human 229 kDa TTC3 protein. -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide derived from the N terminal domain of Human TTC3
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab80061の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ICC/IF |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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特記事項 |
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ICC/IF
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
E3 ubiquitin-protein ligase that mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus. Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation. Catalyzes the formation of 'Lys-48'-polyubiquitin chains. May play a role in neuronal differentiation inhibition via its interaction with CIT. -
組織特異性
Found in all tissues examined. -
パスウェイ
Protein modification; protein ubiquitination. -
配列類似性
Contains 1 RING-type zinc finger.
Contains 4 TPR repeats. -
翻訳後修飾
Phosphorylation on Ser-378 by Akt is required for ubiquitin ligase activity. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 7267 Human
- Omim: 602259 Human
- SwissProt: P53804 Human
- Unigene: 368214 Human
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別名
- DCRR1 antibody
- E3 ubiquitin protein ligase TTC3 antibody
- E3 ubiquitin-protein ligase TTC3 antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (2)
ab80061 は 2 報の論文で使用されています。
- Zhang L et al. A Novel Identified Long Intergenic Noncoding RNA, LINC01574, Contributes to Breast Cancer Deterioration via the Regulation of miR-6745/TTYH3 Axis. J Immunol Res 2022:4201283 (2022). PubMed: 35935583
- Dey-Guha I et al. A mechanism for asymmetric cell division resulting in proliferative asynchronicity. Mol Cancer Res 13:223-30 (2015). WB, ICC/IF ; Human . PubMed: 25582703