製品の概要

  • 製品名Anti-TSPAN12 antibody
    TSPAN12 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TSPAN12
  • アプリケーション適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 180-229 (SCCVREFPGC SKQAHQEDLS DLYQEGCGKK MYSFLRGTKQ LQVLRFLGIS) of Human TSPAN12 (NP_036470).

  • ポジティブ・コントロール
    • Human fetal thymus lysate.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab90091 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. It is a regulator of cell surface receptor signal transduction and plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. It acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. It also acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. It activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP) and activates MMP14/MT1-MMP-dependent cleavage activity.
  • 細胞内局在Cell membrane; Multi-pass membrane protein.
  • 参照データベース
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Anti-TSPAN12 antibody 画像

  • Anti-TSPAN12 antibody (ab90091) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal thymus lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 35 kDa

Anti-TSPAN12 antibody (ab90091) 使用論文

ab90091 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"