製品の概要

  • 製品名
  • 製品の詳細
    Rabbit polyclonal to TSFM
  • アプリケーション
    適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 128-275 of Human TSFM (P43897).

  • ポジティブ・コントロール
    • Jurkat, Raji and K562 whole cell lysates; Gastric cancer tissue.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab125872 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/3000. Predicted molecular weight: 35 kDa.
IHC-P 1/100 - 1/500.

ターゲット情報

  • 機能
    Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
  • 組織特異性
    Expressed in all tissues, with the highest levels of expression in skeletal muscle, liver and kidney.
  • 関連疾患
    Defects in TSFM are the cause of combined oxidative phosphorylation deficiency type 3 (COXPD3) [MIM:610505]. Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases. COXPD3 symptoms include severe metabolic acidosis with encephalomyopathy or with hypertrophic cardiomyopathy. Patients show a severe defect in mitochondrial translation leading to a failure to assemble adequate amounts of three of the oxidative phosphorylation complexes.
  • 配列類似性
    Belongs to the EF-Ts family.
  • 細胞内局在
    Mitochondrion.
  • Information by UniProt
  • 参照データベース
  • 別名
    • COXPD 3 antibody
    • COXPD3 antibody
    • EF TS antibody
    • EF Tsmt antibody
    • EF-Ts antibody
    • EF-TsMt antibody
    • EFTS antibody
    • EFTS_HUMAN antibody
    • EFTSMT antibody
    • Elongation factor Ts antibody
    • Elongation factor Ts mitochondrial antibody
    • HGNC12367 antibody
    • mitochondrial antibody
    • Mitochondrial elongation factor Ts antibody
    • Ts translation elongation factor mitochondrial antibody
    • TSFM antibody
    • TSMT antibody
    see all

画像

  • ab125872, at 1/500, staining TSFM in paraffin-embedded Human gastric cancer tissue by Immunohistochemistry.
  • All lanes : Anti-TSFM antibody (ab125872) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : K562 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 35 kDa

参考文献

ab125872 has not yet been referenced specifically in any publications.

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