製品の概要

  • 製品名Anti-TRPV5 antibody
    TRPV5 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal to TRPV5
  • アプリケーション適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Recombinant fragment: MGGFLPKAEG PGSQLQKLLP SFLVREQDWD QHLDKLHMLQ QKRILESPLL RASKENDLSV LRQLLLDCTC DVRQRGALGE TALHIAALYD NLEAALVLME , corresponding to amino acids 1-101 of Human TRPV5

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファーPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 精製度Protein G purified
  • ポリ/モノモノクローナル
  • アイソタイプIgG1
  • 軽鎖の種類kappa
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab57630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 83 kDa.
ICC/IF Use at an assay dependent dilution. PubMed: 20547482

ターゲット情報

  • 機能Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
  • 組織特異性Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
  • 配列類似性Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily.
    Contains 5 ANK repeats.
  • 翻訳後修飾Glycosylated.
  • 細胞内局在Apical cell membrane. Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Calcium transport protein 2 antibody
    • Calcium transporter 2 antibody
    • CAT 2 antibody
    • CAT2 antibody
    • ECAC 1 antibody
    • ECaC antibody
    • ECaC1 antibody
    • Epithelial calcium channel 1 antibody
    • Osm 9 like TRP channel 3 antibody
    • Osm-9-like TRP channel 3 antibody
    • OTRPC 3 antibody
    • OTRPC3 antibody
    • Transient receptor potential cation channel subfamily V member 5 antibody
    • TRPV 5 antibody
    • TrpV5 antibody
    • TRPV5_HUMAN antibody
    see all

Anti-TRPV5 antibody 画像

  • Anti-TRPV5 antibody (ab57630) + immunogen

    Predicted band size : 83 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Sandwich ELISA. The detection limit for recombinant tagged TRPV5 is approximately 0.03ng/ml as a capture antibody

Anti-TRPV5 antibody (ab57630) 使用論文

This product has been referenced in:
  • Chamoux E  et al. TRPV-5 Mediates a Receptor Activator of NF-{kappa}B (RANK) Ligand-induced Increase in Cytosolic Ca2+ in Human Osteoclasts and Down-regulates Bone Resorption. J Biol Chem 285:25354-62 (2010). ICC/IF ; Human . Read more (PubMed: 20547482) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"