製品の概要

  • 製品名Anti-TRPS1 antibody
    TRPS1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TRPS1
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide derived from Human TRPS1 at N-terminal

  • ポジティブ・コントロール
    • Human lung carcinoma tissue

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes.
  • 組織特異性Ubiquitously expressed in the adult. Found in fetal brain, lung, kidney, liver, spleen and thymus. More highly expressed in androgen-dependent than in androgen-independent prostate cancer cells.
  • 関連疾患Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 1 (TRPS1) [MIM:190350]. TRPS1 is an autosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 3. Typical features include sparse scalp hair, a bulbous tip of the nose, protruding ears, a long flat philtrum and a thin upper vermilion border. Skeletal defects include cone-shaped epiphyses at the phalanges, hip malformations and short stature.
    Defects in TRPS1 are a cause of tricho-rhino-phalangeal syndrome type 2 (TRPS2) [MIM:150230]. A syndrome that combines the clinical features of trichorhinophalangeal syndrome type 1 and multiple exostoses type 1. Affected individuals manifest multiple dysmorphic facial features including large, laterally protruding ears, a bulbous nose, an elongated upper lip, as well as sparse scalp hair, winged scapulae, multiple cartilaginous exostoses, redundant skin, and mental retardation. Note=A chromosomal aberration resulting in the loss of functional copies of TRPS1 and EXT1 has been found in TRPS2 patients.
    Defects in TRPS1 are the cause of tricho-rhino-phalangeal syndrome type 3 (TRPS3) [MIM:190351]. TRPS3 is an autosomal dominant disorder characterized by craniofacial and skeletal abnormalities. It is allelic with tricho-rhino-phalangeal type 1. In TRPS3 a more severe brachydactyly and growth retardation are observed.
  • 配列類似性Contains 7 C2H2-type zinc fingers.
    Contains 1 GATA-type zinc finger.
  • 翻訳後修飾Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites.
  • 細胞内局在Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • GC79 antibody
    • LGCR antibody
    • Tricho rhino phalangeal syndrome I antibody
    • Tricho-rhino-phalangeal syndrome type I protein antibody
    • Trichorhinophalangeal syndrome I antibody
    • Trichorhinophalangeal syndrome I homolog antibody
    • TRPS 1 antibody
    • trpS1 antibody
    • TRPS1 gene antibody
    • TRPS1_HUMAN antibody
    • Zinc finger protein GC79 antibody
    • Zinc finger transcription factor TRPS 1 antibody
    • Zinc finger transcription factor Trps1 antibody
    see all

Anti-TRPS1 antibody 画像

  • ab111439, at 1/50 dilution, staining TRPS1 in paraffin-embedded Human lung carcinoma tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-TRPS1 antibody (ab111439) 使用論文

This product has been referenced in:
  • Hong J  et al. Increased expression of TRPS1 affects tumor progression and correlates with patients' prognosis of colon cancer. Biomed Res Int 2013:454085 (2013). WB, IHC-P ; Human . Read more (PubMed: 23762846) »

See 1 Publication for this product

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