製品の概要

  • 製品名Anti-TRPM3 antibody
    TRPM3 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TRPM3
  • 特異性ab32993 recognises Transient receptor potential cation channel subfamily M member 3 (TRPM3).
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    A region within synthetic peptide: YLRDTPPVPV VVCDGSGRAS DILAFGHKYS EEGGLINESL RDQLLVTIQK, corresponding to internal sequence amino acids 197-246 of Human TRPM3

  • ポジティブ・コントロール
    • Jurkat cell lysate.

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab32993 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA 1/312500.
WB Use a concentration of 2.5 µg/ml. Detects a band of approximately 30 kDa (predicted molecular weight: 37 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

ターゲット情報

  • 関連性Transient receptor potential cation channel, subfamily M, member 3 (TRPM3) belongs to the family of transient receptor potential (TRP) channels. TRP channels are cation selective channels important for cellular calcium signaling and homeostasis. TRPM3 mediates calcium entry, and this entry is potentiated by calcium store depletion. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation. The TRPM3-mediated calcium entry is inhibited by the nonselective calcium channel blocker lanthanide gadolinium. Expressed primarily in the kidney and, at lower levels, in brain, testis, ovary, pancreas and spinal cord. In the kidney, expressed predominantly in the collecting tubular epithelium in the medulla, medullary rays, and periglomerular regions; in the brain, highest levels are found in the cerebellum, choroid plexus, the locus coeruleus, the posterior thalamus and the substantia nigra. Down-regulated in renal tumors compared to normal kidney. Alternatively spliced transcript variants encoding different isoforms have been identified.
  • 細胞内局在Membrane; multi pass membrane protein.
  • 参照データベース
  • 別名
    • GON2 antibody
    • long transient receptor potential channel 3 antibody
    • LTrpC 3 antibody
    • LTRPC3 antibody
    • melastatin 2 antibody
    • Melastatin2 antibody
    • MLSN2 antibody
    • transient receptor potential cation channel, subfamily M, member 3 antibody
    see all

Anti-TRPM3 antibody 画像

  • Anti-TRPM3 antibody (ab32993) at 2.5 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti Rabbit IgG at 1/50000 dilution

    Predicted band size : 37 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

Anti-TRPM3 antibody (ab32993) 使用論文

ab32993 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"