Anti-TRPC6 抗体 [3F2.H10.F2] (ab105845)


  • 製品名Anti-TRPC6 antibody [3F2.H10.F2]
    TRPC6 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [3F2.H10.F2] to TRPC6
  • 特異性Cross-reactivity with TRPC6 from other sources has not been determined.
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee
  • 免疫原

    Synthetic peptide corresponding to a region near the C terminal of Human TRPC6 (NP_004612).

  • ポジティブ・コントロール
    • Human adrenal (cortex) tissue


  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • バッファーpH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride
  • Concentration information loading...
  • 精製度Protein A purified
  • 特記事項(精製)Purified from concentrated tissue culture supernate by Protein A chromatography.
  • ポリ/モノモノクローナル
  • クローン名3F2.H10.F2
  • アイソタイプIgG1
  • 研究分野



Our Abpromise guarantee covers the use of ab105845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/2000. Predicted molecular weight: 106 kDa.
ELISA 1/100000 - 1/50000.
IHC-P Use a concentration of 2.5 µg/ml.


  • 機能Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion.
  • 組織特異性Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm.
  • 関連疾患Defects in TRPC6 are the cause of focal segmental glomerulosclerosis type 2 (FSGS2) [MIM:603965]. A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and edema. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation.
  • 配列類似性Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.
    Contains 4 ANK repeats.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • bZ1P14.9 antibody
    • FLJ11098 antibody
    • FLJ14863 antibody
    • FSGS2 antibody
    • MTRP6 antibody
    • Short transient receptor potential channel 6 antibody
    • si:rp71-1p14.9 antibody
    • Transient receptor potential cation channel subfamily C member 6 antibody
    • Transient receptor protein 6 antibody
    • TRP 6 antibody
    • TRP-6 antibody
    • TRP6 antibody
    • TRPC 6 antibody
    • Trpc6 antibody
    • TRPC6_HUMAN antibody
    • TRRP6 antibody
    see all

Anti-TRPC6 antibody [3F2.H10.F2] 画像

  • ab105845 at 2.5 µg/ml staining TRPC6 in Human adrenal (cortex) tissue by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue.
    The image shows strong staining with minimal background staining. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counterstain.

Anti-TRPC6 antibody [3F2.H10.F2] (ab105845) 使用論文

ab105845 has not yet been referenced specifically in any publications.

Product Wall

Application Western blot
Loading amount 20 µg
Gel Running Conditions Reduced Denaturing (4-15%)
Sample Rabbit Tissue lysate - whole (Ventricle)
Specification Ventricle
Blocking step BSA as blocking agent for 3 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

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投稿 Apr 07 2015

Thank you very much for your interest in our anti-TRPC6 antibodies.

While we do offer six products which work in human tissues, to our knowledge, none of these products have been tested in FACS on human cells. Therefore, I can offer a discoun...

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