製品の概要

  • 製品名Anti-TRPC4 antibody
    TRPC4 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to TRPC4
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Rat, Human
    交差が予測される動物種: Mouse, Cow, Dog
  • 免疫原

    Synthetic peptide:

    C-KHAKEEDSSIDYD

    , corresponding to internal sequence amino acids 948-960 of Human TRPC4 (NP_057263.1).

  • ポジティブ・コントロール
    • Rat Brain lysate; Human Placenta and kidney tissues.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111841 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 112 kDa.
IHC-P Use a concentration of 4.75 µg/ml.

ターゲット情報

  • 機能Form a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
  • 組織特異性Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
  • 配列類似性Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC4 sub-subfamily.
    Contains 4 ANK repeats.
  • ドメインThe protein 4.1-binding domain (654-685) is required for binding to EPB41L2 and channel activation.
    The calmodulin- and inositol 1,4,5-trisphosphate receptor-binding (CIRB) domain (695-724) is sufficient for the interaction with SESTD1.
    The spectrin-binding domain (730-758) is required for binding to SPTAN1 and SPTBN5.
  • 翻訳後修飾Phosphorylation modulates TRPC channel function by regulating the level of TRPC4 at the cell surface and by increasing the association with SLC9A3R1/NHERF.
  • 細胞内局在Membrane. Cell membrane. Enhanced insertion into the cell membrane after activation of the EGF receptor.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CCE1 antibody
    • HTRP 4 antibody
    • hTrp-4 antibody
    • hTrp4 antibody
    • MGC119570 antibody
    • MGC119571 antibody
    • MGC119572 antibody
    • MGC119573 antibody
    • RP11-10M8.1 antibody
    • Short transient receptor potential channel 4 antibody
    • STRPC4 antibody
    • Transient receptor potential 4 antibody
    • transient receptor potential cation channel subfamily C antibody
    • Transient receptor potential cation channel subfamily C member 4 antibody
    • transient receptor potential channel 4 antibody
    • TRP 4 antibody
    • trp related protein 4 antibody
    • Trp-related protein 4 antibody
    • TRP4 antibody
    • TRPC 4 antibody
    • TrpC4 antibody
    • TRPC4 protein antibody
    • TRPC4_HUMAN antibody
    see all

Anti-TRPC4 antibody 画像

  • ab111841, at 4.75µg/ml, staining TRPC4 in Formalin-fixed, Paraffin-embedded Human Kidney tissue by Immunohistochemistry.
  • ab111841, at 4.75µg/ml, staining TRPC4 in Formalin-fixed, Paraffin-embedded Human Placenta tissue by Immunohistochemistry.
  • Anti-TRPC4 antibody (ab111841) at 0.3 µg/ml + Rat Brain lysate at 35 µg
    Developed using the ECL technique

    Predicted band size : 112 kDa


    Exposure time : 1 hour

Anti-TRPC4 antibody (ab111841) 使用論文

ab111841 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"