製品の概要

  • 製品名Anti-TRPC1 antibody
    TRPC1 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TRPC1
  • アプリケーション適用あり: WB, IHC-Frmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Cow, a wide range of other species
  • 免疫原

    Synthetic peptide derived from the C-terminal domain of TRPC1

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab75322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/200 - 1/2000. Predicted molecular weight: 91 kDa.
IHC-Fr Use at an assay dependent concentration.

ターゲット情報

  • 機能Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.
  • 組織特異性Seems to be ubiquitous.
  • 配列類似性Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.
    Contains 4 ANK repeats.
  • 翻訳後修飾Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • HTRP 1 antibody
    • HTRP1 antibody
    • MGC133334 antibody
    • MGC133335 antibody
    • Mtrp1 antibody
    • Short transient receptor potential channel 1 antibody
    • Transient receptor potential canonical 1 antibody
    • Transient receptor potential cation channel subfamily C member 1 antibody
    • Transient receptor potential channel 1 antibody
    • Transient receptor protein 1 antibody
    • TRP 1 antibody
    • TRP 1 protein antibody
    • Trp related protein 1 antibody
    • TRP-1 antibody
    • TRP1 antibody
    • TRP1 protein antibody
    • TRPC1 antibody
    • Trpc1 transient receptor potential cation channel subfamily C member 1 antibody
    • TRPC1_HUMAN antibody
    • Trrp1 antibody
    see all

Anti-TRPC1 antibody 画像



  • Predicted band size : 91 kDa

    Image from Woodard GE et al, J Biol Chem. 2010 Mar 12;285(11):8045-53. Epub 2009 Dec 18, Fig 5. DOI 10.1074/jbc.M109.033605

Anti-TRPC1 antibody (ab75322) 使用論文

This product has been referenced in:
  • Pullen NA  et al. Novel Mechanism for Fc{epsilon}RI-mediated Signal Transducer and Activator of Transcription 5 (STAT5) Tyrosine Phosphorylation and the Selective Influence of STAT5B over Mast Cell Cytokine Production. J Biol Chem 287:2045-54 (2012). WB ; Mouse . Read more (PubMed: 22130676) »
  • Woodard GE  et al. TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1. J Biol Chem 285:8045-53 (2010). WB ; Human . Read more (PubMed: 20022948) »

See all 3 Publications for this product

Product Wall

Application Immunohistochemistry (Frozen sections)
Sample Human Tissue sections (hepatocelluar cell carcinoma)
Permeabilization No
Specification hepatocelluar cell carcinoma
Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 10% · Temperature: 25°C
Fixative Acetone
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投稿 Aug 19 2016

Application Western blot
Loading amount 25 µg
Gel Running Conditions Reduced Denaturing
Sample Human Cell lysate - whole cell (liver, Hep G2)
Specification liver, Hep G2
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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投稿 Jan 19 2015

Application Western blot
Loading amount 20 µg
Gel Running Conditions Reduced Denaturing (8% gel)
Sample Mouse Tissue lysate - whole (lung)
Specification lung
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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投稿 Jul 16 2013

Thank you for contacting us and your patience. I am sorry to hear you have been experiencing problems with our TRPC1 antibodies. I appreciate the time you have spent in the laboratory and understand your concerns. It is regrettable the results have ...

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Thank you very much for your email. I am very sorry and concerned to hear that you are experiencing problems with two of our antibodies. I would like to investigate this problem further. Can you therefore please provide an image of the results obtained...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"