Anti-TRP1 抗体 [Ta99], prediluted (ab11781)

製品の概要

  • 製品名
    Anti-TRP1 antibody [Ta99], prediluted
    TRP1 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [Ta99] to TRP1, prediluted
  • 特異性
    This monoclonal antibody detects a differentiation related, pigmentation-associated glycoprotein (gp75), expressed by melanoma cells, nomal melanocytes and nevi. This antibody does not react with carcinomas and sarcomas.
  • アプリケーション
    適用あり: IHC-Frmore details
  • 種交差性
    交差種: Human
  • 免疫原

    SK-MEL-23 Melanoma cell line

  • ポジティブ・コントロール
    • Human melanoma or normal skin. Normal mouse serum is included with this product as a negative control.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab11781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-Fr
  • 追加情報
    IHC-Fr: Use at an assay dependent dilution. For optimal staining, the primary antibody should be incubated 20-60 minutes at room temperature.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
    • 組織特異性
      Pigment cells.
    • パスウェイ
      Pigment biosynthesis; melanin biosynthesis.
    • 関連疾患
      Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
    • 配列類似性
      Belongs to the tyrosinase family.
    • 細胞内局在
      Melanosome membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 5 antibody
      • 5,6 dihydroxyindole 2 carboxylic acid oxidase antibody
      • 6-dihydroxyindole-2-carboxylic acid oxidase antibody
      • b-PROTEIN antibody
      • CAS2 antibody
      • Catalase B antibody
      • CATB antibody
      • DHICA oxidase antibody
      • Glycoprotein 75 antibody
      • GP75 antibody
      • Melanoma antigen gp75 antibody
      • OCA3 antibody
      • TRP antibody
      • TRP-1 antibody
      • TRP1 antibody
      • Tyrosinase related protein 1 antibody
      • Tyrosinase-related protein 1 antibody
      • TYRP antibody
      • TYRP1 antibody
      • TYRP1_HUMAN antibody
      • TYRRP antibody
      see all

    プロトコール

    参考文献

    ab11781 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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