Anti-Tropomyosin 1 (alpha) 抗体 (ab118875)

製品の概要

  • 製品名Anti-Tropomyosin 1 (alpha) antibody
    Tropomyosin 1 (alpha) 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Tropomyosin 1 (alpha)
  • アプリケーション適用あり: WB, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Cow, Pig
  • 免疫原

    Recombinant full length Human Tropomyosin 1 (alpha) protein.

  • ポジティブ・コントロール
    • Human spleen and tonsil tissues; A431 cell lysate

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab118875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use at an assay dependent concentration. Predicted molecular weight: 33 kDa.
IHC-P Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
  • 組織特異性Detected in primary breast cancer tissues but undetectable in normal breast tissues in Sudanese patients. Isoform 1 is expressed in adult and fetal skeletal muscle and cardiac tissues, with higher expression levels in the cardiac tissues. Isoform 10 is expressed in adult and fetal cardiac tissues, but not in skeletal muscle.
  • 関連疾患Defects in TPM1 are the cause of cardiomyopathy familial hypertrophic type 3 (CMH3) [MIM:115196]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    Defects in TPM1 are the cause of cardiomyopathy dilated type 1Y (CMD1Y) [MIM:611878]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 配列類似性Belongs to the tropomyosin family.
  • ドメインThe molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • 細胞内局在Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AA986836 antibody
    • AI854628 antibody
    • Alpha tropomyosin antibody
    • alpha-TM antibody
    • Alpha-tropomyosin antibody
    • C15orf13 antibody
    • cardiomyopathy, hypertrophic 3 antibody
    • CMD1Y antibody
    • CMH3 antibody
    • HTM alpha antibody
    • HTM-alpha antibody
    • OTTHUMP00000163688 antibody
    • sarcomeric tropomyosin kappa antibody
    • TM2 antibody
    • Tmpa antibody
    • TMSA antibody
    • Tpm-1 antibody
    • TPM1 antibody
    • TPM1_HUMAN antibody
    • tropomyosin 1 (alpha) antibody
    • tropomyosin 1 (alpha) isoform 1 antibody
    • tropomyosin 1 (alpha) isoform 2 antibody
    • tropomyosin 1 (alpha) isoform 3 antibody
    • tropomyosin 1 (alpha) isoform 4 antibody
    • tropomyosin 1 (alpha) isoform 5 antibody
    • tropomyosin 1 (alpha) isoform 6 antibody
    • tropomyosin 1 (alpha) isoform 7 antibody
    • Tropomyosin 1 antibody
    • Tropomyosin alpha 1 chain antibody
    • Tropomyosin alpha-1 chain antibody
    • Tropomyosin, skeletal muscle alpha antibody
    • Tropomyosin-1 antibody
    see all

Anti-Tropomyosin 1 (alpha) antibody 画像

  • Anti-Tropomyosin 1 (alpha) antibody (ab118875) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 33 kDa
  • ab118875, at 10 µg/ml, staining Tropomyosin 1 (alpha) in formalin fixed, paraffin embedded Human spleen tissue by Immunohistochemistry.
  • ab118875, at 10 µg/ml, staining Tropomyosin 1 (alpha) in formalin fixed, paraffin embedded Human tonsil tissue by Immunohistochemistry.

Anti-Tropomyosin 1 (alpha) antibody (ab118875) 使用論文

ab118875 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"