製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to TrkC
  • 特異性
    This antibody is specific for rat TrkC at 145kDa and an additional band at approximately 100kDa.
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Mouse, Rat, Human
    交差が予測される動物種: Chicken, Pig
  • 免疫原

    Recombinant entire extracellular domain of rat TrkC receptor, corresponding to aa1-429, expressed in COS cells.

  • ポジティブ・コントロール
    • Mouse brain membrane protein preparation.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab33656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 145 kDa (predicted molecular weight: 68 kDa).

ターゲット情報

  • 機能
    Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.
  • 組織特異性
    Widely expressed but mainly in nervous tissue. Isoform B is expressed at higher levels in adult brain than in fetal brain.
  • 配列類似性
    Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾
    Ligand-mediated auto-phosphorylation.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EC 2.7.10.1 antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion antibody
    • ETS related protein neurotrophic receptor tyrosine kinase fusion protein antibody
    • ETV6 NTRK3 fusion antibody
    • GP145 TrkC antibody
    • gp145(trkC) antibody
    • GP145-TrkC antibody
    • GP145TrkC antibody
    • Neurotrophic tyrosine kinase receptor type 3 antibody
    • Neurotrophin 3 receptor antibody
    • NT 3 growth factor receptor antibody
    • NT 3 growth factor receptor precursor antibody
    • NT 3 receptor antibody
    • NT-3 growth factor receptor antibody
    • Ntrk3 antibody
    • NTRK3_HUMAN antibody
    • OTTHUMP00000192915 antibody
    • TRK C antibody
    • Trk-C antibody
    • TRKC antibody
    • TrkC tyrosine kinase antibody
    • Tyrosine kinase receptor C antibody
    see all

プロトコール

参考文献

This product has been referenced in:
  • Boyarchuk E  et al. The histone variant composition of centromeres is controlled by the pericentric heterochromatin state during the cell cycle. J Cell Sci 127:3347-59 (2014). Read more (PubMed: 24906798) »

See 1 Publication for this product

レビューと Q&A

Thank you for your enquiry. The immunogen for this product comprises the entire extracellular domain of rat TrkC receptor, corresponding to 1-429a.a, expressed in COS cells. Three isoforms of TrkC (isoforms A, B and C) differ in their amino aci...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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