Anti-TrkB (phospho Y706 + Y707) 抗体 (ab111545)

製品の概要

  • 製品名Anti-TrkB (phospho Y706 + Y707) antibody
    TrkB 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TrkB (phospho Y706 + Y707)
  • 特異性ab111545 detects endogenous levels of Trk B only when phosphorylated at tyrosine 706 and tyrosine 707 (Human: Tyr706+Tyr707; Mouse: Tyr705+Tyr706; Rat: Tyr705+Tyr706).
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat
  • 免疫原

    Synthetic phosphopeptide derived from Human TrkB around the phosphorylation site of Tyrosine 706 and Tyrosine 707.

  • ポジティブ・コントロール
    • Human brain tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
  • 組織特異性Isoform TrkB is widely expressed, mainly in the nervous tissue. In the CNS, expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophtalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is expressed in multiple tissues, mainly in brain, pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in brain.
  • 配列類似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
    Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 2 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Ligand-mediated auto-phosphorylation.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • AI848316 antibody
    • BDNF tropomyosine receptor kinase B antibody
    • BDNF/NT 3 growth factors receptor antibody
    • BDNF/NT-3 growth factors receptor antibody
    • Brain derived neurotrophic factor receptor antibody
    • C030027L06Rik antibody
    • EC 2.7.10.1 antibody
    • GP145 TrkB antibody
    • GP145-TrkB antibody
    • GP145-TrkB/GP95-TrkB antibody
    • GP95 TrkB antibody
    • Neurotrophic tyrosine kinase receptor type 2 antibody
    • Neurotrophin receptor tyrosine kinase type 2 antibody
    • NTRK 2 antibody
    • Ntrk2 antibody
    • NTRK2_HUMAN antibody
    • Obesity, hyperphagia, and developmental delay, included antibody
    • RATTRKB1 antibody
    • Tkrb antibody
    • Trk B antibody
    • Trk-B antibody
    • TRKB antibody
    • TrkB tyrosine kinase antibody
    • TRKB1 antibody
    • Tropomyosin related kinase B antibody
    • tyrosine kinase receptor B antibody
    • Tyrosine receptor kinase B antibody
    see all

Anti-TrkB (phospho Y706 + Y707) antibody 画像

  • ab111545, at 1/50 dilution, staining TrkB in paraffin-embedded Human brain tissue by Immunohistochemistry, in the presence (right panel) or absence (left panel) of immunising peptide.

Anti-TrkB (phospho Y706 + Y707) antibody (ab111545) 使用論文

ab111545 has not yet been referenced specifically in any publications.

Product Wall

Merci d'avoir répondu au questionnaire qui vous a été envoyé. Je suis désolé que les anticorps que vous avez testés ne puissent pas discriminer la TrkA et laTrkC. Comme le montrent les alignements de s&e...

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Le laboratoire où est produit l'anticorps ab111545 m'a informé qu'aucun test n'avait été effectué avec TrkA ou TrkC mais que la détection est très probable due à l'homologie de séquence autour des tyrosines 706 et 707. J'espère que ces informations ...

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Merci de nous avoir contactés. Comme convenu j'ai mis en place l'envoi d'une unité gratuite de ab111545 (www.abcam.com/ab111545), le numéro de la commande est : ******. Concernant le possible croisement de l'anticorps ab111545 avec les protéines ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"