Anti-TRIM71/LIN41 抗体 (ab105330)
Key features and details
- Rabbit polyclonal to TRIM71/LIN41
- Suitable for: WB, ICC
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-TRIM71/LIN41 antibody -
製品の詳細
Rabbit polyclonal to TRIM71/LIN41 -
由来種
Rabbit -
アプリケーション
適用あり: WB, ICCmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide corresponding to Human TRIM71/LIN41 (C terminal).
Database link: Q2Q1W2 -
ポジティブ・コントロール
- Human brain tissue lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab105330の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB | (2) |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 93 kDa.
|
ICC |
Use a concentration of 5 - 20 µg/ml.
|
特記事項 |
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WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 93 kDa. |
ICC
Use a concentration of 5 - 20 µg/ml. |
ターゲット情報
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機能
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. -
組織特異性
Specifically expressed in testis. -
パスウェイ
Protein modification; protein ubiquitination. -
配列類似性
Belongs to the TRIM/RBCC family.
Contains 2 B box-type zinc fingers.
Contains 1 filamin repeat.
Contains 6 NHL repeats.
Contains 1 RING-type zinc finger. -
翻訳後修飾
Autoubiquitinated. -
細胞内局在
Cytoplasm, P-body. - Information by UniProt
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参照データベース
- Entrez Gene: 131405 Human
- SwissProt: Q2Q1W2 Human
- Unigene: 113170 Human
- Unigene: 567678 Human
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別名
- 2610206G21Rik antibody
- Abnormal cell LINeage LIN 41 antibody
- AL022943 antibody
see all
画像
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Lane 1 : Anti-TRIM71/LIN41 antibody (ab105330) at 1 µg/ml
Lane 2 : Anti-TRIM71/LIN41 antibody (ab105330) at 2 µg/ml
All lanes : Human brain tissue lysate
Lysates/proteins at 15 µg per lane.
Secondary
All lanes : Anti-rabbit secondary antibody
Predicted band size: 93 kDa -
Immunohistochemistry of TRIM71/LIN41 in human brain tissue with ab105330 at 5 µg/ml.
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Immunofluorescence of TRIM71/LIN41 in Human Brain cells using ab105330 at 20 ug/ml.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab105330 は 2 報の論文で使用されています。
- Han F et al. MicroRNA-4491 enhances cell proliferation and inhibits cell apoptosis in non-small cell lung cancer via targeting TRIM7. Oncol Lett 22:591 (2021). PubMed: 34149902
- Robinton DA et al. The Lin28/let-7 Pathway Regulates the Mammalian Caudal Body Axis Elongation Program. Dev Cell 48:396-405.e3 (2019). PubMed: 30661985