製品の概要

  • 製品名Anti-TRIM21 antibody
    TRIM21 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TRIM21
  • アプリケーション適用あり: IPmore details
    適用なし: WB
  • 種交差性
    交差種: Human
    交差が予測される動物種: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide corresponding to Human TRIM21 aa 250-300 (internal sequence).
    Sequence:

    VLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITLDPDTANPW L


    Database link: NP_003132.2

  • ポジティブ・コントロール
    • HeLa cell lysate

製品の特性

関連製品

アプリケーション

Our Abpromise guarantee covers the use of ab91425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP
  • 追加情報IP: Use at 5-15µg/mg of lysate.

    Is unsuitable for WB.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能E3 ubiquitin-protein ligase whose activity is dependent on E2 enzymes, UBE2D1, UBE2D2, UBE2E1 and UBE2E2. Forms a ubiquitin ligase complex in cooperation with the E2 UBE2D2 that is used not only for the ubiquitination of USP4 and IKBKB but also for its self-ubiquitination. Component of cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes such as SCF(SKP2)-like complexes. A TRIM21-containing SCF(SKP2)-like complex is shown to mediate ubiquitination of CDKN1B ('Thr-187' phosphorylated-form), thereby promoting its degradation by the proteasome. Monoubiquitinates IKBKB that will negatively regulates Tax-induced NF-kappa-B signaling. Negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3. Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain, which is linked to the VCP-mediated ER-associated degradation (ERAD) pathway. Promotes IRF8 ubiquitination, which enhanced the ability of IRF8 to stimulate cytokine genes transcription in macrophages. Plays a role in the regulation of the cell cycle progression. Enhances the decapping activity of DCP2. Exists as a ribonucleoprotein particle present in all mammalian cells studied and composed of a single polypeptide and one of four small RNA molecules. At least two isoforms are present in nucleated and red blood cells, and tissue specific differences in RO/SSA proteins have been identified. The common feature of these proteins is their ability to bind HY RNAs.2.
    • 組織特異性Isoforms 1 and 2 are expressed in fetal and adult heart and fetal lung.
    • パスウェイProtein modification; protein ubiquitination.
    • 配列類似性Belongs to the TRIM/RBCC family.
      Contains 1 B box-type zinc finger.
      Contains 1 B30.2/SPRY domain.
      Contains 1 RING-type zinc finger.
    • ドメインThe coiled-coil is necessary for the cytoplasmic localization. The B30.2/SPRY domain is necessary for the cytoplasmic localization, the interaction with IRF3 and for the IRF3-driven interferon beta promoter activity. The RING-type zinc finger is necessary for ubiquitination and for the IRF3-driven interferon beta promoter activity. Interacts with SKP2 and CUL1 in a RING finger-independent manner.
    • 翻訳後修飾Autoubiquitinated; does not lead to its proteasomal degradation. Deubiquitinated by USP4; leading to its stabilization.
    • 細胞内局在Cytoplasm. Nucleus. Cytoplasm > P-body. Enters the nucleus upon exposure to nitric oxide. Localizes to small dot- or rod-like structures in the cytoplasm, called cytoplasmic bodies (P-body) that are located underneath the plasma membrane and also diffusely in the cytoplasm and are highly motil in cells. Cytoplasmic bodies are located along the microtubules and do not share the same cytoplasmic bodies with TRIM5. Colocalizes with DCP2 in P-body.
    • Information by UniProt
    • 参照データベース
    • 別名
      • 52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody
      • 52 kDa Ro protein antibody
      • 52kD Ro/SSA autoantigen antibody
      • Autoantigen Ro/SSA, 52-KD antibody
      • E3 ubiquitin-protein ligase TRIM21 antibody
      • RING finger protein 81 antibody
      • RNF81 antibody
      • Ro 52 antibody
      • Ro(SS-A) antibody
      • Ro52 antibody
      • RO52_HUMAN antibody
      • Sicca syndrome antigen A antibody
      • Sjoegren syndrome type A antigen antibody
      • Sjogren syndrome antigen A1 antibody
      • Sjogren syndrome type A antigen antibody
      • SS-A antibody
      • SSA antibody
      • SSA1: Sjogren syndrome antigen A1 (52kDa ribonucleoprotein autoantigen SS-A/Ro) antibody
      • TRIM21 antibody
      • Tripartite motif protein TRIM21 antibody
      • Tripartite motif-containing 21 antibody
      • Tripartite motif-containing protein 21 antibody
      see all

    Anti-TRIM21 antibody (ab91425) 使用論文

    ab91425 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"