製品の概要

  • 製品名Anti-TRIM11 antibody
    TRIM11 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TRIM11
  • アプリケーション適用あり: IHC-P, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 1-155 of Human TRIM11.

  • ポジティブ・コントロール
    • 293T, A431, Jurkat and Raji whole cell lysates; Human Hepatoma tissue.

法規制情報

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.

ターゲット情報

  • 機能E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
  • 組織特異性Ubiquitous.
  • パスウェイProtein modification; protein ubiquitination.
  • 配列類似性Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • ドメインThe coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
    The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
  • 細胞内局在Cytoplasm. Nucleus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • BIA 1 antibody
    • E3 ubiquitin protein ligase TRIM11 antibody
    • E3 ubiquitin-protein ligase TRIM11 antibody
    • Protein BIA1 antibody
    • RING finger protein 92 antibody
    • RNF 92 antibody
    • TRI11_HUMAN antibody
    • Trim 11 antibody
    • TRIM11 antibody
    • Tripartite motif containing 11 antibody
    • tripartite motif protein 11 antibody
    • Tripartite motif-containing protein 11 antibody
    see all

Anti-TRIM11 antibody 画像

  • Anti-TRIM11 antibody (ab111694) at 1/2000 dilution + Jurkat whole cell lysate at 30 µg

    Predicted band size : 53 kDa
  • ab111694 at 1/500 dilution staining TRIM11 in Formalin-fixed, paraffin-embedded Human Hepatoma tissue by Immunohistochemistry.

Anti-TRIM11 antibody (ab111694) 使用論文

ab111694 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"