Anti-TRF1 抗体 (ab13792)

製品の概要

• 製品名Anti-TRF1 antibody
  TRF1 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to TRF1
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide:

  LFLSKLQHGTQQQDL

  , corresponding to amino acids 321-335 of Human TRF1
  Run BLAST with Run BLAST with
• ポジティブ･コントロール
  • 293 cell lysate.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: 0.05% Sodium Azide
  Constituents: 0.05% BSA, PBS
• Concentration information loading...
• 精製度Protein G purified
• 特記事項（精製）This antibody is affinity purified.
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Epigenetics and Nuclear Signaling
  • Chromosome Structure
  • Telomeres

  • Tags & Cell Markers
  • Subcellular Markers
  • Nucleus
  • Chromatin

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HEK293 whole cell lysate (ab7902)

アプリケーション

ターゲット情報

• 機能Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
• 組織特異性Highly expressed and ubiquitous. Isoform Pin2 predominates.
• 配列類似性Contains 1 HTH myb-type DNA-binding domain.
• ドメインThe acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.
  The TRFH dimerization region mediates the interaction with TINF2.
• 翻訳後修飾Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
  ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.
  Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
• 細胞内局在Nucleus. Cytoplasm > cytoskeleton > spindle. Chromosome > telomere. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.

• Target information above from: UniProt accession P54274 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 7013 Human
  • Omim: 600951 Human
  • SwissProt: P54274 Human
  • Unigene: 442707 Human
• 別名
  • hTRF1 AS antibody
  • NIMA interacting protein 2 antibody
  • NIMA-interacting protein 2 antibody

  • PIN 2 antibody
  • PIN2 antibody
  • t TRF1 antibody
  • Telomeric protein Pin2 antibody
  • Telomeric protein Pin2/TRF1 antibody
  • Telomeric repeat binding factor (NIMA interacting) 1 antibody
  • Telomeric repeat binding factor 1 antibody
  • Telomeric repeat binding protein 1 antibody
  • Telomeric repeat-binding factor 1 antibody
  • TERF 1 antibody
  • Terf1 antibody
  • TERF1_HUMAN antibody
  • TRBF 1 antibody
  • TRBF1 antibody
  • TRF 1 antibody
  • TRF antibody
  • TTAGGG repeat binding factor 1 antibody
  • TTAGGG repeat-binding factor 1 antibody

  see all