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機能
Binds the telomeric double-stranded TTAGGG repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
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組織特異性
Highly expressed and ubiquitous. Isoform Pin2 predominates.
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配列類似性
Contains 1 HTH myb-type DNA-binding domain.
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ドメイン
The acidic N-terminal domain binds to the ankyrin repeats of TNKS1 and TNKS2. The C-terminal domain binds microtubules.
The TRFH dimerization region mediates the interaction with TINF2.
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翻訳後修飾
Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage.
ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA.
Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome.
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細胞内局在
Nucleus. Cytoplasm > cytoskeleton > spindle. Chromosome > telomere. Colocalizes with telomeric DNA in interphase and metaphase cells and is located at chromosome ends during metaphase. Associates with the mitotic spindle.
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Information by UniProt
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参照データベース
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別名
- hTRF1 AS antibody
- NIMA interacting protein 2 antibody
- NIMA-interacting protein 2 antibody
- PIN 2 antibody
- PIN2 antibody
- t TRF1 antibody
- Telomeric protein Pin2 antibody
- Telomeric protein Pin2/TRF1 antibody
- Telomeric repeat binding factor (NIMA interacting) 1 antibody
- Telomeric repeat binding factor 1 antibody
- Telomeric repeat binding protein 1 antibody
- Telomeric repeat-binding factor 1 antibody
- TERF 1 antibody
- Terf1 antibody
- TERF1_HUMAN antibody
- TRBF 1 antibody
- TRBF1 antibody
- TRF 1 antibody
- TRF antibody
- TTAGGG repeat binding factor 1 antibody
- TTAGGG repeat-binding factor 1 antibody
see all