Anti-TREM1 抗体 (ab104413)
Key features and details
- Rabbit polyclonal to TREM1
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
製品の概要
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製品名
Anti-TREM1 antibody
TREM1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TREM1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Recombinant full length protein within Human TREM1 aa 1-250. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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ポジティブ・コントロール
- Mouse kidney tissue lysate; TREM1 transfected 293T cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Constituent: 100% PBS -
Concentration information loading...
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精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab104413の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB | (1) |
Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa.
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特記事項 |
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WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 26 kDa. |
ターゲット情報
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機能
Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. -
組織特異性
Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes. -
配列類似性
Contains 1 Ig-like V-type (immunoglobulin-like) domain. -
翻訳後修飾
Glycosylated. -
細胞内局在
Secreted and Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 54210 Human
- Entrez Gene: 58217 Mouse
- Omim: 605085 Human
- SwissProt: Q9NP99 Human
- SwissProt: Q9JKE2 Mouse
- Unigene: 283022 Human
- Unigene: 248352 Mouse
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別名
- CD354 antibody
- OTTMUSP00000018206 antibody
- TREM 1 antibody
see all
画像
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Anti-TREM1 antibody (ab104413) at 1 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 26 kDa -
All lanes : Anti-TREM1 antibody (ab104413) at 1 µg/ml
Lane 1 : TREM1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 26 kDa
データシートおよび資料
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Datasheet download
参考文献 (8)
ab104413 は 8 報の論文で使用されています。
- Yao L et al. Shengxian decoction decreases doxorubicin-induced cardiac apoptosis by regulating the TREM1/NF-?B signaling pathway. Mol Med Rep 23:N/A (2021). PubMed: 33495812
- Wang L et al. Cigarette smoke extract-treated airway epithelial cells-derived exosomes promote M1 macrophage polarization in chronic obstructive pulmonary disease. Int Immunopharmacol 96:107700 (2021). PubMed: 34000706
- Li J et al. Transcriptomic Profiling Reveals a Role for TREM-1 Activation in Enterovirus D68 Infection-Induced Proinflammatory Responses. Front Immunol 12:749618 (2021). PubMed: 34887856
- Feng CW et al. Therapeutic Effect of Modulating TREM-1 via Anti-inflammation and Autophagy in Parkinson's Disease. Front Neurosci 13:769 (2019). PubMed: 31440123
- Liu F et al. TREM1: A positive regulator for inflammatory response via NF-?B pathway in A549 cells infected with Mycoplasma pneumoniae. Biomed Pharmacother 107:1466-1472 (2018). PubMed: 30257363
- Shi R et al. Expression level of 12-amino acid triggering receptor on myeloid cells-like transcript 1 derived peptide alleviates lipopolysaccharide-induced acute lung injury in mice. Int J Mol Med 41:2159-2168 (2018). PubMed: 29393375
- Tammaro A et al. Effect of TREM-1 blockade and single nucleotide variants in experimental renal injury and kidney transplantation. Sci Rep 6:38275 (2016). PubMed: 27928159
- Tammaro A et al. Role of TREM1-DAP12 in renal inflammation during obstructive nephropathy. PLoS One 8:e82498 (2013). WB ; Mouse, Human . PubMed: 24358193