Anti-Treacher Collins syndrome protein 抗体 - ChIP Grade (ab65212)


  • 製品名Anti-Treacher Collins syndrome protein antibody - ChIP Grade
    Treacher Collins syndrome protein 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Treacher Collins syndrome protein - ChIP Grade
  • アプリケーション適用あり: ChIP, WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    A synthetic peptide derived from the internal region of human Treacher Collins syndrome protein.

  • ポジティブ・コントロール
    • Human lung carcinoma tissue and extracts from Jurkat cells



Our Abpromise guarantee covers the use of ab65212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ChIP Use at an assay dependent concentration. PubMed: 20591827
WB 1/500 - 1/1000. Detects a band of approximately 152 kDa (predicted molecular weight: 152 kDa).
IHC-P 1/50 - 1/100.
ELISA 1/10000.


  • 機能May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex.
  • 関連疾患Defects in TCOF1 are the cause of Treacher Collins syndrome type 1 (TCS1) [MIM:154500]. It is a form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss.
  • 配列類似性Contains 1 LisH domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus > nucleolus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Mandibulofacial dysostosis antibody
    • MFD1 antibody
    • Nucleolar trafficking phosphoprotein antibody
    • TCOF 1 antibody
    • TCOF_HUMAN antibody
    • TCOF1 antibody
    • TCS antibody
    • TCS1 antibody
    • Treacher Collins Franceschetti syndrome 1 antibody
    • Treacher Collins syndrome antibody
    • Treacher Collins syndrome protein antibody
    • Treacle antibody
    • Treacle protein antibody
    see all

Anti-Treacher Collins syndrome protein antibody - ChIP Grade 画像

  • All lanes : Anti-Treacher Collins syndrome protein antibody - ChIP Grade (ab65212) at 1/500 dilution

    Lane 1 : Extracts from Jurkat cells
    Lane 2 : Extracts from Jurkat cells, plus immunising peptide

    Predicted band size : 152 kDa
    Observed band size : 152 kDa
    The amount of positive control loading for the WB is 5-30 ug of total protein.
    The amount of the peptide for the WB is 5-10 ug.
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ab65212 at a 1:50 dilution.
    Left image untreated.
    Right image treated with immunising peptide.

Anti-Treacher Collins syndrome protein antibody - ChIP Grade (ab65212) 使用論文

This product has been referenced in:
  • Stixová L  et al. HP1ß-dependent recruitment of UBF1 to irradiated chromatin occurs simultaneously with CPDs. Epigenetics Chromatin 7:39 (2014). ICC/IF ; Mouse . Read more (PubMed: 25587355) »
  • Zentner GE  et al. CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet 19:3491-501 (2010). WB, ChIP ; Mouse . Read more (PubMed: 20591827) »

See all 2 Publications for this product

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