Anti-Treacher Collins syndrome protein 抗体 - ChIP Grade (ab65212)

製品の概要

  • 製品名Anti-Treacher Collins syndrome protein antibody - ChIP Grade
    Treacher Collins syndrome protein 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Treacher Collins syndrome protein - ChIP Grade
  • アプリケーション適用あり: ChIP, WB, IHC-P, ELISAmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    A synthetic peptide derived from the internal region of human Treacher Collins syndrome protein.

  • ポジティブ・コントロール
    • Human lung carcinoma tissue and extracts from Jurkat cells

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab65212 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ChIP Use at an assay dependent concentration. PubMed: 20591827
WB 1/500 - 1/1000. Detects a band of approximately 152 kDa (predicted molecular weight: 152 kDa).
IHC-P 1/50 - 1/100.
ELISA 1/10000.

ターゲット情報

  • 機能May be involved in nucleolar-cytoplasmic transport. May play a fundamental role in early embryonic development, particularly in development of the craniofacial complex.
  • 関連疾患Defects in TCOF1 are the cause of Treacher Collins syndrome type 1 (TCS1) [MIM:154500]. It is a form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss.
  • 配列類似性Contains 1 LisH domain.
  • 翻訳後修飾Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 細胞内局在Nucleus > nucleolus.
  • Information by UniProt
  • 参照データベース
  • 別名
    • Mandibulofacial dysostosis antibody
    • MFD1 antibody
    • Nucleolar trafficking phosphoprotein antibody
    • TCOF 1 antibody
    • TCOF_HUMAN antibody
    • TCOF1 antibody
    • TCS antibody
    • TCS1 antibody
    • Treacher Collins Franceschetti syndrome 1 antibody
    • Treacher Collins syndrome antibody
    • Treacher Collins syndrome protein antibody
    • Treacle antibody
    • Treacle protein antibody
    see all

Anti-Treacher Collins syndrome protein antibody - ChIP Grade 画像

  • All lanes : Anti-Treacher Collins syndrome protein antibody - ChIP Grade (ab65212) at 1/500 dilution

    Lane 1 : Extracts from Jurkat cells
    Lane 2 : Extracts from Jurkat cells, plus immunising peptide


    Predicted band size : 152 kDa
    Observed band size : 152 kDa
  • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ab65212 at a 1:50 dilution.
    Left image untreated.
    Right image treated with immunising peptide.

Anti-Treacher Collins syndrome protein antibody - ChIP Grade (ab65212) 使用論文

This product has been referenced in:
  • Zentner GE  et al. CHD7 functions in the nucleolus as a positive regulator of ribosomal RNA biogenesis. Hum Mol Genet 19:3491-501 (2010). WB, ChIP ; Mouse . Read more (PubMed: 20591827) »

See 1 Publication for this product

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