Anti-Transferrin Receptor (phospho S24) 抗体 (ab61021)

製品の概要

  • 製品名Anti-Transferrin Receptor (phospho S24) antibody
    Transferrin Receptor 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to Transferrin Receptor (phospho S24)
  • 特異性Detects endogenous levels of Transferrin Receptor only when phosphorylated at serine 24.
  • アプリケーション適用あり: WB, ELISA, IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic phosphopeptide derived from human Transferrin Receptor around the phosphorylation site of serine 24 (R-F-SP-L-A).

  • ポジティブ・コントロール
    • Human brain tissue 293 cells, treated with PMA

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab61021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/500 - 1/1000. Detects a band of approximately 85 kDa (predicted molecular weight: 85 kDa).
ELISA 1/10000.
IHC-P 1/50 - 1/100.

ターゲット情報

  • 機能Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
    (Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus.
  • 関連疾患Immunodeficiency 46
  • 配列類似性Belongs to the peptidase M28 family. M28B subfamily.
    Contains 1 PA (protease associated) domain.
  • 翻訳後修飾N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
    Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
    Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
  • 細胞内局在Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 71 antibody
    • CD71 antibody
    • CD71 antigen antibody
    • OTTHUMP00000208523 antibody
    • OTTHUMP00000208524 antibody
    • OTTHUMP00000208525 antibody
    • p90 antibody
    • sTfR antibody
    • T9 antibody
    • TFR 1 antibody
    • TfR antibody
    • TfR1 antibody
    • TFR1_HUMAN antibody
    • TFRC antibody
    • TR antibody
    • Transferrin receptor (p90 CD71) antibody
    • Transferrin receptor protein 1, serum form antibody
    • Trfr antibody
    see all

Anti-Transferrin Receptor (phospho S24) antibody 画像

  • Immunohistochemical analysis of paraffin-embedded human brain tissue using ab61021 at a dilution of 1/50.
  • All lanes : Anti-Transferrin Receptor (phospho S24) antibody (ab61021)

    Lane 1 : extracts from 293 cells, treated with PMA (125ng/ml, 30mins)
    Lane 2 : extracts from 293 cells, treated with PMA (125ng/ml, 30mins) with Immunizing phospho-peptide


    Predicted band size : 85 kDa
    Observed band size : 85 kDa

Anti-Transferrin Receptor (phospho S24) antibody (ab61021) 使用論文

ab61021 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"