Concentration varies from lot to lot and can be provided on request.
Abcam is committed to meeting high standards of ethical manufacturing and has decided to discontinue this product by June 2019 as it has been generated by the ascites method. We are sorry for any inconvenience this may cause.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution.
Use at an assay dependent dilution. Can be used as both coating and conjugate antibody when paired with recommended pair for detection of transferrin.
1/500. Detects a band of approximately 77 kDa (predicted molecular weight: 77 kDa).
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
Expressed by the liver and secreted in plasma.
Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:209300]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.
Belongs to the transferrin family. Contains 2 transferrin-like domains.
Shakor AB et al. Sphingomyelin Synthase 1-generated Sphingomyelin Plays an Important Role in Transferrin Trafficking and Cell Proliferation. J Biol Chem286:36053-62 (2011).
Read more (PubMed: 21856749) »
Grønborg M et al. Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach. Mol Cell Proteomics5:157-71 (2006).
Read more (PubMed: 16215274) »