The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 66 kDa (predicted molecular weight: 66.8 kDa).
機能Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis.
組織特異性Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and peripheral blood.
配列類似性Belongs to the TNF receptor-associated factor family. A subfamily. Contains 1 MATH domain. Contains 1 RING-type zinc finger. Contains 2 TRAF-type zinc fingers.
ドメインThe MATH/TRAF domain binds to receptor cytoplasmic domains.