製品の概要

  • 製品名
  • 製品の詳細
    Mouse polyclonal to TRAF4
  • アプリケーション
    適用あり: WB, ICC/IFmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Full length human TRAF4 protein (NP_004286.2).

  • ポジティブ・コントロール
    • WB: human pancreas tissue lysate, TRAF4 transfected 293T cell lysate ICC/IF: HeLa cell

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab88612 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 54 kDa.
ICC/IF Use a concentration of 10 µg/ml.

ターゲット情報

  • 機能
    Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.
  • 組織特異性
    Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus.
  • 配列類似性
    Belongs to the TNF receptor-associated factor family. B subfamily.
    Contains 1 MATH domain.
    Contains 1 RING-type zinc finger.
    Contains 3 TRAF-type zinc fingers.
  • ドメイン
    The coiled coil domain mediates homo- and hetero-oligomerization.
    The MATH/TRAF domain binds to receptor cytoplasmic domains.
  • 翻訳後修飾
    Polyubiquitinated, leading to its proteasomal degradation.
  • 細胞内局在
    Cytoplasm. Nucleus. Cytoplasm > perinuclear region. Cell junction > tight junction. Cell membrane. Cytoplasm > cytoskeleton.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CART 1 antibody
    • CART1 antibody
    • cysteine rich domain associated with ring and TRAF domain antibody
    • Cysteine rich domain associated with RING and Traf domains protein 1 antibody
    • Cysteine-rich domain associated with RING and Traf domains protein 1 antibody
    • Malignant 62 antibody
    • Metastatic lymph node gene 62 protein antibody
    • MLN 62 antibody
    • MLN62 antibody
    • RING finger protein 83 antibody
    • RNF 83 antibody
    • RNF83 antibody
    • TNF receptor associated factor 4 antibody
    • TNF receptor-associated factor 4 antibody
    • TRAF 4 antibody
    • Traf4 antibody
    • TRAF4_HUMAN antibody
    • tumor necrosis receptor-associated factor 4A antibody
    see all

画像

  • Anti-TRAF4 antibody (ab88612) at 1 µg/ml + human pancreas tissue lysate at 50 µg

    Predicted band size : 54 kDa
    Observed band size : 45 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-TRAF4 antibody (ab88612) at 1 µg/ml

    Lane 1 : TRAF4 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 54 kDa
    Observed band size : 54 kDa
  • ab88612, at 10 µg/ml, staining TRAF4 on HeLa cell by Immunofluorescence.

参考文献

ab88612 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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