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機能
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
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配列類似性
Belongs to the TNF receptor-associated factor family. A subfamily.
Contains 1 MATH domain.
Contains 1 RING-type zinc finger.
Contains 2 TRAF-type zinc fingers.
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ドメイン
The MATH/TRAF domain binds to receptor cytoplasmic domains.
The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.
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翻訳後修飾
Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling (By similarity). Deubiquitinated by OTUB1, OTUB2 and OTUD5.
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細胞内局在
Cytoplasm. Endosome. Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.
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Information by UniProt
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参照データベース
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別名
- CAP 1 antibody
- CAP-1 antibody
- CAP1 antibody
- CD40 associated protein 1 antibody
- CD40 binding protein antibody
- CD40 bp antibody
- CD40 receptor associated factor 1 antibody
- CD40 receptor-associated factor 1 antibody
- CD40-binding protein antibody
- CD40BP antibody
- CRAF 1 antibody
- CRAF1 antibody
- IIAE5 antibody
- LAP 1 antibody
- LAP1 antibody
- LMP1 associated protein antibody
- LMP1-associated protein 1 antibody
- MIPT3 antibody
- TNF receptor associated factor 3 antibody
- TNF receptor-associated factor 3 antibody
- TRAF 3 antibody
- Traf3 antibody
- TRAF3_HUMAN antibody
see all