Anti-TRAF3 抗体 (ab62552)

製品の概要

• 製品名
  Anti-TRAF3 antibody
  TRAF3 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to TRAF3
• アプリケーション
  適用あり: WB, ICC/IFmore details
• 種交差性
  交差種: Mouse, Human
  
• 免疫原

  A 16 amino acid peptide from near the carboxy terminus of human TRAF3.

• ポジティブ･コントロール
  • 3T3 cell lysate.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Store at +4°C.
• バッファー
  Preservative: 0.02% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Cancer
  • Growth factors
  • TNF

  • Cancer
  • Invasion/microenvironment
  • Apoptosis
  • Death receptors & ligands
  • TRAF

  • Cancer
  • Cell Death
  • Apoptosis
  • Receptors
  • Death receptors & ligands
  • TRAF

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 機能
  Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
• 配列類似性
  Belongs to the TNF receptor-associated factor family. A subfamily.
  Contains 1 MATH domain.
  Contains 1 RING-type zinc finger.
  Contains 2 TRAF-type zinc fingers.
• ドメイン
  The MATH/TRAF domain binds to receptor cytoplasmic domains.
  The Ring-type zinc finger domain is required for its function in down-regulation of NFKB2 proteolytic processing.
• 翻訳後修飾
  Undergoes 'Lys-48'-linked polyubiquitination, leading to its proteasomal degradation in response to signaling by TNFSF13B, TLR4 or through CD40. Undergoes 'Lys-63'-linked ubiquitination during early stages of virus infection, and 'Lys-48'-linked ubiquitination during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked ubiquitination in response to TLR3 and TLR4 signaling (By similarity). Deubiquitinated by OTUB1, OTUB2 and OTUD5.
• 細胞内局在
  Cytoplasm. Endosome. Mitochondrion. Undergoes endocytosis together with TLR4 upon LPS signaling (By similarity). Associated with mitochondria in response to virus.

• Target information above from: UniProt accession Q13114 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 7187 Human
  • Entrez Gene: 22031 Mouse
  • Omim: 601896 Human
  • SwissProt: Q13114 Human
  • SwissProt: Q60803 Mouse
  • Unigene: 510528 Human
  • Unigene: 27431 Mouse
• 別名
  • CAP 1 antibody
  • CAP-1 antibody
  • CAP1 antibody

  • CD40 associated protein 1 antibody
  • CD40 binding protein antibody
  • CD40 bp antibody
  • CD40 receptor associated factor 1 antibody
  • CD40 receptor-associated factor 1 antibody
  • CD40-binding protein antibody
  • CD40BP antibody
  • CRAF 1 antibody
  • CRAF1 antibody
  • IIAE5 antibody
  • LAP 1 antibody
  • LAP1 antibody
  • LMP1 associated protein antibody
  • LMP1-associated protein 1 antibody
  • MIPT3 antibody
  • TNF receptor associated factor 3 antibody
  • TNF receptor-associated factor 3 antibody
  • TRAF 3 antibody
  • Traf3 antibody
  • TRAF3_HUMAN antibody

  see all

プロトコール

• Western blot protocols
• Immunocytochemistry & immunofluorescence protocols