製品の概要

  • 製品名Anti-TRAF1 antibody
    TRAF1 一次抗体 製品一覧
  • 製品の詳細
    Goat polyclonal to TRAF1
  • アプリケーション適用あり: ELISA, WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide:

    C-KLQSPKHAYVKDD

    , corresponding to C terminal amino acids 392-404 of Human TRAF1

  • ポジティブ・コントロール
    • U937 cell lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab48002 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
ELISA
WB
  • 追加情報ELISA: Use at an assay dependent dilution. Antibody detection limit dilution 1:16,000
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 55 kDa (predicted molecular weight: 46 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
    • 配列類似性Contains 1 MATH domain.
    • ドメインThe coiled coil domain mediates homo- and hetero-oligomerization.
      The MATH/TRAF domain binds to receptor cytoplasmic domains.
      Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling.
    • 翻訳後修飾Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
    • Information by UniProt
    • 参照データベース
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    Anti-TRAF1 antibody 画像

    Anti-TRAF1 antibody (ab48002) 使用論文

    ab48002 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab48002.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"