Anti-TPR 抗体 (ab59679)

製品の概要

• 製品名
  Anti-TPR antibody
  TPR 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to TPR
• アプリケーション
  適用あり: WBmore details
• 種交差性
  交差種: Human
  
• 免疫原

  Synthetic peptide (Human) of TPR

• ポジティブ･コントロール
  • HeLa and 293T cell lysates.

製品の特性

• 製品の状態
  Liquid
• 保存方法
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• バッファー
  Preservative: 0.02% Thimerosal (merthiolate)
  Constituents: 30% Glycerol, 1% BSA, PBS
• Concentration information loading...
• 精製度
  Immunogen affinity purified
• ポリ/モノ
  ポリクローナル
• アイソタイプ
  IgG
• 研究分野
  • Signal Transduction
  • Protein Trafficking
  • Nuclear Import / Export

  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • Other

  • Cancer
  • Cell cycle
  • Kinases/phosphatases
  • Other

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Positive Controls
  • HeLa nuclear extract lysate (ab14655)

アプリケーション

ターゲット情報

• 機能
  Component of the cytoplasmic fibrils of the nuclear pore complex implicated in nuclear protein import. Its N-terminus is involved in activation of oncogenic kinases. Plays a role in the mitotic spindle checkpoint.
• 組織特異性
  Highest in testis, lung, thymus, spleen and brain, lower levels in heart, liver and kidney.
• 関連疾患
  Defects in TPR are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=Chromosomal aberrations involving TPR are found in thyroid papillary carcinomas. Intrachromosomal rearrangement that links the 5'-end of the TPR gene to the protein kinase domain of NTRK1 forms the fusion protein TRK-T1. TRK-T1 is a 55 kDa protein reacting with antibodies against the carboxy terminus of the NTRK1 protein.
  Note=Involved in tumorigenic rearrangements with the MET or RAF genes.
• 翻訳後修飾
  Phosphorylated upon DNA damage, probably by ATM or ATR.
• 細胞内局在
  Nucleus > nuclear pore complex. Nucleus membrane. Chromosome > centromere > kinetochore. The assembly of the NPC is a stepwise process in which Trp-containing peripheral structures assemble after other components, including p62. Detected at kinetochores during prometaphase.

• Target information above from: UniProt accession P12270 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 7175 Human
  • Omim: 189940 Human
  • SwissProt: P12270 Human
  • Unigene: 279640 Human
• 別名
  • Nucleoprotein TPR antibody
  • tpr antibody
  • TPR_HUMAN antibody
  • translocated promoter region (to activated MET oncogene) antibody

プロトコール

• Western blot protocols