Anti-TPP1 抗体 (ab96498)
Key features and details
- Rabbit polyclonal to TPP1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
-
製品名
Anti-TPP1 antibody
TPP1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TPP1 -
由来種
Rabbit -
特異性
This product detects Tripeptidyl-peptidase 1 (TPP1). It is unable to detect Adrenocortical dysplasia protein homolog which is also known as TPP1.
-
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow, Dog -
免疫原
Recombinant protein fragment containing a sequence corresponding to a region within amino acids 224 and 562 of TPP1 (NP_000382)
-
ポジティブ・コントロール
- A431 whole cell lysate and H1299, HeLa, HepG2 lysates
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
-
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab96498の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 61 kDa.
|
特記事項 |
---|
WB
1/500 - 1/3000. Predicted molecular weight: 61 kDa. |
ターゲット情報
-
機能
Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. -
組織特異性
Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. -
関連疾患
Defects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2) [MIM:204500]. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles. -
配列類似性
Belongs to the peptidase S53 family. -
翻訳後修飾
Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity. -
細胞内局在
Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
-
参照データベース
- Entrez Gene: 515575 Cow
- Entrez Gene: 485337 Dog
- Entrez Gene: 1200 Human
- Entrez Gene: 12751 Mouse
- Entrez Gene: 83534 Rat
- Omim: 607998 Human
- SwissProt: Q0V8B6 Cow
- SwissProt: Q9XSB8 Dog
see all -
別名
- Cell growth inhibiting gene 1 protein antibody
- Cell growth-inhibiting gene 1 protein antibody
- Ceroid lipofuscinosis neuronal 2 antibody
see all
画像
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (3)
ab96498 は 3 報の論文で使用されています。
- Huang K et al. Identification of three predictors of gastric cancer progression and prognosis. FEBS Open Bio 10:1891-1899 (2020). PubMed: 32735728
- Shlevkov E et al. A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport. Cell Rep 28:3224-3237.e5 (2019). PubMed: 31533043
- Chandra S et al. Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARa. J Neurosci 38:6682-6699 (2018). PubMed: 29967008