製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to TPP1
  • アプリケーション
    適用あり: WBmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Cow, Dog, Chimpanzee, Cynomolgus monkey
  • 免疫原

    Synthetic peptide:

    C-TPSVIRKRYNLTSQD

    , corresponding to internal sequence amino acids 201-215 of Human TPP1 (NP_000382.3).

  • ポジティブ・コントロール
    • Human placenta lysate

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab91512 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
  • 追加情報
    WB: Use at a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 65 kDa (predicted molecular weight: 61 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能
      Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus.
    • 組織特異性
      Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues.
    • 関連疾患
      Defects in TPP1 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2) [MIM:204500]. A form of neuronal ceroid lipofuscinosis. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy. The lipopigment pattern seen most often in CLN2 consists of curvilinear profiles.
    • 配列類似性
      Belongs to the peptidase S53 family.
    • 翻訳後修飾
      Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity.
    • 細胞内局在
      Lysosome. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
    • Information by UniProt
    • 参照データベース
    • 別名
      • Cell growth inhibiting gene 1 protein antibody
      • Cell growth-inhibiting gene 1 protein antibody
      • Ceroid lipofuscinosis neuronal 2 antibody
      • Ceroid lipofuscinosis neuronal 2 late infantile (Jansky Bielschowsky disease) antibody
      • Ceroid lipofuscinosis neuronal 2 late infantile antibody
      • CLN 2 antibody
      • CLN2 antibody
      • GIG 1 antibody
      • GIG1 antibody
      • Growth inhibiting protein 1 antibody
      • LPIC antibody
      • Lysosomal pepstatin insensitive protease antibody
      • Lysosomal pepstatin-insensitive protease antibody
      • MGC21297 antibody
      • TPP 1 antibody
      • TPP I antibody
      • TPP-1 antibody
      • TPP-I antibody
      • Tpp1 antibody
      • TPP1_HUMAN antibody
      • TPPI antibody
      • Tripeptidyl aminopeptidase antibody
      • Tripeptidyl peptidase I antibody
      • Tripeptidyl-peptidase 1 antibody
      • Tripeptidyl-peptidase I antibody
      see all

    画像

    • Anti-TPP1 antibody (ab91512) at 0.3 µg/ml + Human placenta lysate at 35 µg
      Developed using the ECL technique

      Predicted band size : 61 kDa
      Observed band size : 65 kDa (why is the actual band size different from the predicted?)


      Exposure time : 1 hour

    プロトコール

    参考文献

    ab91512 has not yet been referenced specifically in any publications.

    レビューと Q&A

    There are currently no Customer reviews or Questions for ab91512.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    登録