Anti-TPH2 抗体 (ab125877)

製品の概要

• 製品名Anti-TPH2 antibody
  TPH2 一次抗体 製品一覧
• 製品の詳細
  Rabbit polyclonal to TPH2
• アプリケーション適用あり: WBmore details
• 種交差性
  交差種: Human, Baboon
  交差が予測される動物種: Mouse, Rat, Chicken, Dog, Monkey, Zebrafish
• 免疫原

  Recombinant fragment corresponding to Human TPH2 aa 178-465.
  Database link: Q8IWU9

• ポジティブ･コントロール
  • IMR32 whole cell lysate U87-MG whole cell lysate

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーpH: 7.00
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 78% PBS, 20% Glycerol, 1% BSA
• Concentration information loading...
• 精製度Immunogen affinity purified
• ポリ/モノポリクローナル
• アイソタイプIgG
• 研究分野
  • Neuroscience
  • Neurotransmitter
  • Biogenic Amines
  • Serotonin / 5HT

  • Signal Transduction
  • Metabolism
  • Amino Acids

  • Neuroscience
  • Neurotransmission
  • Intracellular Signaling
  • Regulation

関連製品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

アプリケーション

ターゲット情報

• 組織特異性Brain specific.
• パスウェイAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
• 関連疾患Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
  Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders.
• 配列類似性Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
  Contains 1 ACT domain.

• Target information above from: UniProt accession Q8IWU9 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 121278 Human
  • Entrez Gene: 216343 Mouse
  • Entrez Gene: 317675 Rat
  • Entrez Gene: 407712 Zebrafish
  • Omim: 607478 Human
  • SwissProt: Q8IWU9 Human
  • SwissProt: Q8CGV2 Mouse
  • SwissProt: Q8CGU9 Rat

  • SwissProt: Q1LUE3 Zebrafish
  • Unigene: 376337 Human
  • Unigene: 31597 Mouse
  • Unigene: 28510 Rat

  see all
• 別名
  • MGC138871 antibody
  • ADHD7 antibody
  • FLJ37295 antibody

  • MGC138872 antibody
  • Neuronal tryptophan hydroxylase antibody
  • NTPH antibody
  • TPH 2 antibody
  • Tph2 antibody
  • TPH2_HUMAN antibody
  • Tryptophan 5-hydroxylase 2 antibody
  • Tryptophan 5-monooxygenase 2 antibody
  • Tryptophan hydroxylase 2 antibody

  see all