製品の概要
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製品名Anti-TPH2 antibody
TPH2 一次抗体 製品一覧 -
製品の詳細Rabbit polyclonal to TPH2
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由来種Rabbit
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アプリケーション適用あり: WBmore details
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種交差性交差種: Human, Baboon
交差が予測される動物種: Mouse, Rat, Chicken, Dog, Monkey, Zebrafish
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免疫原
Recombinant fragment corresponding to Human TPH2 aa 178-465.
Database link: Q8IWU9 -
ポジティブ･コントロール
- IMR32 whole cell lysate U87-MG whole cell lysate
法規制情報
製品の特性
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製品の状態Liquid
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保存方法Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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バッファーpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78% PBS, 20% Glycerol, 1% BSA -
Concentration information loading... -
精製度Immunogen affinity purified
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ポリ/モノポリクローナル
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アイソタイプIgG
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研究分野
関連製品
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Compatible Secondaries
アプリケーション
Our Abpromise guarantee covers the use of ab125877 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | 1/500 - 1/3000. Predicted molecular weight: 56 kDa. |
ターゲット情報
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組織特異性Brain specific.
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パスウェイAromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.
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関連疾患Genetic variation in TPH2 may influence susceptibility to major depressive disorder (MDD) [MIM:608516].
Defects in TPH2 are the cause of susceptibility to attention deficit-hyperactivity disorder type 7 (ADHD7) [MIM:613003]. ADHD is a neurobehavioral developmental disorder and is primarily characterized by the co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone. Note=Naturally occurring variants of TPH2 with impaired enzyme activity could cause deficiency of serotonin production and result in an increased risk of developing behavioral disorders. -
配列類似性Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Contains 1 ACT domain. - Information by UniProt
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参照データベース
- Entrez Gene: 121278 Human
- Entrez Gene: 216343 Mouse
- Entrez Gene: 317675 Rat
- Entrez Gene: 407712 Zebrafish
- Omim: 607478 Human
- SwissProt: Q8IWU9 Human
- SwissProt: Q8CGV2 Mouse
- SwissProt: Q8CGU9 Rat
see all -
別名
- MGC138871 antibody
- ADHD7 antibody
- FLJ37295 antibody
see all
画像
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Western blot - Anti-TPH2 antibody (ab125877)All lanes : Anti-TPH2 antibody (ab125877) at 1/1000 dilution
Lane 1 : IMR32 whole cell lysate
Lane 2 : U87-MG whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 56 kDa
10% SDS PAGE
プロトコール
参考文献
ab125877 has not yet been referenced specifically in any publications.
レビューと Q&A
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"