製品の概要

  • 製品名Anti-TORC2 antibody
    TORC2 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TORC2
  • 特異性These antiboy does not cross react to human lactoferrin, bovine lactoferrin or bovine serum albumin.
  • アプリケーション適用あり: WB, ELISAmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide corresponding to an unique epitope on the Torc2 protein. The peptide was covalently modified post synthetically and covalently coupled to a carrier protein for desired antigenicity before injecting in to rabbits.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab88035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB
ELISA
  • 追加情報ELISA: 1/10000.
    WB: 1/500. Detects a band of approximately 85 kDa (predicted molecular weight: 73 kDa). The antibody also labels a 55 kDa protein believed to be a smaller variant of Torc2.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • ターゲット情報

    • 機能Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
    • 組織特異性Most abundantly expressed in the thymus. Present in both B and T lymphocytes. Highly expressed in HEK293T cells and in insulinomas. High levels also in spleen, ovary, muscle and lung, with highest levels in muscle. Lower levels found in brain, colon, heart, kidney, prostate, small intestine and stomach. Weak expression in liver and pancreas.
    • 配列類似性Belongs to the TORC family.
    • 翻訳後修飾Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1. Both insulin and AMPK increase this phosphorylation, of TORC2 while glucagon suppresses it.
    • 細胞内局在Cytoplasm. Nucleus. Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein. In response to cAMP levels and glucagon, relocated to the nucleus.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CREB regulated transcription coactivator 2 antibody
      • CREB-regulated transcription coactivator 2 antibody
      • CRTC2 antibody
      • CRTC2_HUMAN antibody
      • RP11-422P24.6 antibody
      • TORC-2 antibody
      • torc2 antibody
      • Transducer of CREB protein 2 antibody
      • Transducer of regulated cAMP response element-binding protein antibody
      • Transducer of regulated cAMP response element-binding protein (CREB) 2 antibody
      • Transducer of regulated cAMP response element-binding protein 2 antibody
      • Transducer of regulated CREB protein 2 antibody
      see all

    Anti-TORC2 antibody (ab88035) 使用論文

    ab88035 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"