製品の概要

  • 製品名
    Tobramycin, free base
  • 製品の詳細
    Ribosomal translation inhibitor
  • 生理活性の詳細
    Inhibits ribosomal translation. Aminoglycoside antibiotic which binds 30S ribosomal subunit A, preventing functional protein production. Effective against gram-negative bacteria.
  • 精製度
    > 98%

製品の特性

参考文献

This product has been referenced in:
  • Pignatello R  et al. Amphiphilic ion pairs of tobramycin with lipoamino acids. Eur J Med Chem 46:1665-71 (2011). Read more (PubMed: 21396748) »
  • Hobbie SN  et al. Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction. Antimicrob Agents Chemother 49:5112-8 (2005). Read more (PubMed: 16304180) »
  • Walter F  et al. Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation. EMBO J 21:760-8 (2002). Read more (PubMed: 11847123) »

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