製品の概要

  • 製品名Anti-TNIK antibody
    TNIK 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TNIK
  • アプリケーション適用あり: IHC-Pmore details
  • 種交差性
    交差種: Human
    交差が予測される動物種: Mouse
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids of Human TNIK (BAA25477.2).

  • ポジティブ・コントロール
    • Human Skeletal Muscle tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab115619 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading.
  • 組織特異性Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues.
  • 配列類似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • 翻訳後修飾Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
  • 細胞内局在Nucleus. Cytoplasm. Recycling endosome. Cytoplasm > cytoskeleton. Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
  • Information by UniProt
  • 参照データベース
  • 別名
    • EC 2.7.11.1 antibody
    • KIAA0551 antibody
    • Tnik antibody
    • TNIK_HUMAN antibody
    • Traf2 and NCK interacting kinase antibody
    • Traf2 and NCK-interacting protein kinase antibody
    see all

Anti-TNIK antibody 画像

  • ab115619, at 5µg/ml, staining TNIK in Formalin-fixed, Paraffin-embedded Human skeletal muscle (myocytes) tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TNIK antibody (ab115619) 使用論文

ab115619 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"