製品の概要

  • 製品名Anti-TNFRSF1A antibody
    TNFRSF1A 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TNFRSF1A
  • アプリケーション適用あり: WB, IP, IHC-Pmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Sheep, Rabbit, Hamster, Cow, Dog, Human, Pig, Saccharomyces cerevisiae, Xenopus laevis, Drosophila melanogaster, Monkey
  • 免疫原

    Synthetic peptide derived from a sequence within Mouse TNFRSF1A.

  • ポジティブ・コントロール
    • Human Brain Cortex tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 12.5 µg/ml. Predicted molecular weight: 50 kDa.
IP Use a concentration of 12.5 µg/ml.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • 関連疾患Defects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
  • 配列類似性Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • ドメインThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
  • 翻訳後修飾The soluble form is produced from the membrane form by proteolytic processing.
  • 細胞内局在Cell membrane. Secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD120a antibody
    • FPF antibody
    • MGC19588 antibody
    • p55 antibody
    • p55 R antibody
    • P55R antibody
    • p60 antibody
    • TBP 1 antibody
    • TBP1 antibody
    • TBPI antibody
    • TNF R antibody
    • TNF R I antibody
    • TNF R55 antibody
    • TNF-R1 antibody
    • TNF-RI antibody
    • TNFAR antibody
    • TNFR 55 antibody
    • TNFR 60 antibody
    • TNFR antibody
    • TNFR-I antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFR60 antibody
    • TNFRI antibody
    • TNFRSF1A antibody
    • TNR1A_HUMAN antibody
    • Tumor necrosis factor alpha receptor antibody
    • Tumor necrosis factor binding protein 1 antibody
    • Tumor necrosis factor receptor 1 antibody
    • Tumor necrosis factor receptor superfamily member 1A antibody
    • Tumor necrosis factor receptor type 1 antibody
    • Tumor necrosis factor receptor type I antibody
    • Tumor necrosis factor-binding protein 1 antibody
    see all

Anti-TNFRSF1A antibody 画像

  • ab111119, at 10µg/ml, staining TNFRSF1A in formalin-fixed, paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-TNFRSF1A antibody (ab111119) 使用論文

ab111119 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your response.

Of the products which may react in canine only ab13918 has been tested in IHC and WB. However I would still recommend ab22106 as the homology of the regions is greater and it is a polyclonal antibody. You would q...

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Thank you for your response, I apologize as it seem that I lost track of the protein names. We have a few products against RANKwhichshould work with canine samples as the homologies between the protein regions is good. Of those products I would reco...

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Thank you for contacting Abcam. The alignment of the human and canine proteins are very good. As such I can offer you a testing discount for ab107860 (http://www.abcam.com/TNFRSF1A-antibody-ab107860.html) orab111119(http://www.abcam.com/TNFRSF1A-antibo...

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Thank you for contacting us. Unfortunately we cannot offer free samples for the product in our catalog. With well over 60,000 products available, the logistics of having sample sizes would be overwhelming. However, we stand behind our products with the...

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