製品の概要

  • 製品名Anti-TNF Receptor II antibody [HM102]
    TNF Receptor II 一次抗体 製品一覧
  • 製品の詳細
    Rat monoclonal [HM102] to TNF Receptor II
  • 特異性Mouse TNF-R II and the soluble receptor.
  • アプリケーション適用あり: IP, IHC-Fr, Flow Cytmore details
  • 種交差性
    交差種: Mouse
  • エピトープExtra-cellular part of the receptor.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab7369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
IP
IHC-Fr
Flow Cyt
  • 追加情報The antibody is an agonistic antibody useful for cell culture experiments and for detection of TNF-R II by FACS analysis.
    Furthermore it can be used for immunoprecipitation and histology on frozen sections.
    The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-?.
  • ターゲット情報

    • 機能Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
    • 配列類似性Contains 4 TNFR-Cys repeats.
    • 翻訳後修飾Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
      A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
    • 細胞内局在Secreted and Cell membrane.
    • Information by UniProt
    • 参照データベース
    • 別名
      • CD120b antibody
      • p75 antibody
      • p75 TNF receptor antibody
      • p75TNFR antibody
      • p80 TNF alpha receptor antibody
      • p80 TNF-alpha receptor antibody
      • Soluble TNFR1B variant 1 antibody
      • TBP-2 antibody
      • TBPII antibody
      • TNF R II antibody
      • TNF R2 antibody
      • TNF R75 antibody
      • TNF-R2 antibody
      • TNF-RII antibody
      • TNFBR antibody
      • TNFR-II antibody
      • TNFR1B antibody
      • TNFR2 antibody
      • TNFR80 antibody
      • TNFRII antibody
      • Tnfrsf1b antibody
      • TNR1B_HUMAN antibody
      • Tumor necrosis factor beta receptor antibody
      • Tumor necrosis factor receptor 2 antibody
      • Tumor necrosis factor receptor superfamily member 1B antibody
      • Tumor necrosis factor receptor type II antibody
      • Tumor necrosis factor-binding protein 2 antibody
      see all

    Anti-TNF Receptor II antibody [HM102] (ab7369) 使用論文

    This product has been referenced in:
    • Tesz GJ  et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . Read more (PubMed: 17500068) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry and patience. Our source for this antibody was able to provide me with the following information. The agonistic properties of the antibody were tested in a proliferation assay with mouse thymocytes (H-thymidine uptake was mea...

    Read More

    We do not know of any references, although this is a very popular antibody so there are probably some which we are unaware of. We are about to set up an automatic publication update system which should help us identify and then publish references for A...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"