ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
追加情報Is unsuitable for ICC,IHC-P or IP.
機能Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
関連疾患Familial hibernian fever Multiple sclerosis 5
配列類似性Contains 1 death domain. Contains 4 TNFR-Cys repeats.
ドメインThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE. Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
翻訳後修飾The soluble form is produced from the membrane form by proteolytic processing.
細胞内局在Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
Tumor necrosis factor receptor superfamily, member 1A antibody
Tumor necrosis factor receptor type 1 antibody
Tumor necrosis factor receptor type I antibody
Tumor necrosis factor-binding protein 1 antibody
Anti-TNF Receptor I antibody [EP1651AY] 画像
Western blot - TNF Receptor I antibody [EP1651AY] (ab68160)
Anti-TNF Receptor I antibody [EP1651AY] (ab68160) at 1/500 dilution + human brain tissue lysate at 10 µg
Secondary HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size : 51 kDa Observed band size : 51 kDa
Anti-TNF Receptor I antibody [EP1651AY] (ab68160) 使用論文
This product has been referenced in:
Zhu W et al. Comparison of the properties of human CD146+ and CD146- periodontal ligament cells in response to stimulation with tumour necrosis factor a. Arch Oral Biol58:1791-803 (2013).
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