Anti-TNF Receptor I 抗体 (ab90463)
Key features and details
- Rabbit polyclonal to TNF Receptor I
- Suitable for: WB
- Reacts with: Human, Saccharomyces cerevisiae
- Isotype: IgG
製品の概要
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製品名
Anti-TNF Receptor I antibody
TNF Receptor I 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TNF Receptor I -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human, Saccharomyces cerevisiae -
免疫原
Synthetic peptide derived from the sequence of mouse TNF Receptor 1
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.09% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab90463の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
特記事項 |
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WB (ECL): 1/1000. Predicted molecular weight: 51 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. -
関連疾患
Familial hibernian fever
Multiple sclerosis 5 -
配列類似性
Contains 1 death domain.
Contains 4 TNFR-Cys repeats. -
ドメイン
The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP. -
翻訳後修飾
The soluble form is produced from the membrane form by proteolytic processing. -
細胞内局在
Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 7132 Human
- Omim: 191190 Human
- SwissProt: P19438 Human
- Unigene: 279594 Human
- Unigene: 713833 Human
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別名
- CD120a antibody
- FPF antibody
- MGC19588 antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab90463 は 5 報の論文で使用されています。
- Li Q et al. TRPV4-induced Müller cell gliosis and TNF-α elevation-mediated retinal ganglion cell apoptosis in glaucomatous rats via JAK2/STAT3/NF-κB pathway. J Neuroinflammation 18:271 (2021). PubMed: 34789280
- Duan Z et al. Inhibition of microRNA-155 Reduces Neuropathic Pain During Chemotherapeutic Bortezomib via Engagement of Neuroinflammation. Front Oncol 10:416 (2020). PubMed: 32296644
- You L et al. Overexpression of miR-29a-3p Suppresses Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells in Atherosclerosis via Targeting TNFRSF1A. Biomed Res Int 2020:9627974 (2020). PubMed: 32964047
- Li C et al. Blocking TRPA1 and TNF-a Signal Improves Bortezomib-Induced Neuropathic Pain. Cell Physiol Biochem 51:2098-2110 (2018). PubMed: 30522101
- Zhou Z et al. Inhibition of Epithelial TNF-a Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis. Front Immunol 8:1468 (2017). PubMed: 29176974