Anti-TNF Receptor I 抗体 (ab111119)

製品の概要

  • 製品名
    Anti-TNF Receptor I antibody
    TNF Receptor I 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TNF Receptor I
  • アプリケーション
    適用あり: WB, IP, IHC-Pmore details
  • 種交差性
    交差種: Mouse
    交差が予測される動物種: Rat, Sheep, Rabbit, Hamster, Cow, Dog, Human, Pig, Saccharomyces cerevisiae, Xenopus laevis, Drosophila melanogaster, Monkey
  • 免疫原

    Synthetic peptide within Mouse TNF Receptor I. The exact sequence is proprietary.

  • ポジティブ・コントロール
    • IHC-P: Human Brain Cortex tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab111119 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 12.5 µg/ml. Predicted molecular weight: 50 kDa.
IP Use a concentration of 12.5 µg/ml.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

ターゲット情報

  • 機能
    Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • 関連疾患
    Familial hibernian fever
    Multiple sclerosis 5
  • 配列類似性
    Contains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • ドメイン
    The domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
  • 翻訳後修飾
    The soluble form is produced from the membrane form by proteolytic processing.
  • 細胞内局在
    Cell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD120a antibody
    • FPF antibody
    • MGC19588 antibody
    • p55 antibody
    • p55-R antibody
    • p60 antibody
    • TBP1 antibody
    • TBPI antibody
    • TNF R antibody
    • TNF R55 antibody
    • TNF-R1 antibody
    • TNF-RI antibody
    • TNFAR antibody
    • TNFR-I antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFR60 antibody
    • TNFRI antibody
    • TNFRSF1a antibody
    • TNR1A_HUMAN antibody
    • Tumor necrosis factor receptor 1 antibody
    • Tumor necrosis factor receptor superfamily, member 1A antibody
    • Tumor necrosis factor receptor type 1 antibody
    • Tumor necrosis factor receptor type I antibody
    • Tumor necrosis factor-binding protein 1 antibody
    see all

画像

  • ab111119, at 10µg/ml, staining TNF Receptor I in formalin-fixed, paraffin-embedded Human brain cortex tissue by Immunohistochemistry followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

参考文献

ab111119 has not yet been referenced specifically in any publications.

レビューと Q&A

Thank you for your response.

Of the products which may react in canine only ab13918 has been tested in IHC and WB. However I would still recommend ab22106 as the homology of the regions is greater and it is a polyclonal antibody. You would q...

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Thank you for your response, I apologize as it seem that I lost track of the protein names. We have a few products against RANKwhichshould work with canine samples as the homologies between the protein regions is good. Of those products I would reco...

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Thank you for contacting Abcam. The alignment of the human and canine proteins are very good. As such I can offer you a testing discount for ab107860 (http://www.abcam.com/TNFRSF1A-antibody-ab107860.html) orab111119(http://www.abcam.com/TNFRSF1A-antibo...

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Thank you for contacting us. Unfortunately we cannot offer free samples for the product in our catalog. With well over 60,000 products available, the logistics of having sample sizes would be overwhelming. However, we stand behind our products with the...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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