Anti-TNF alpha 抗体 [MP6-XT3] (ab11564)

製品の概要

• 製品名Anti-TNF alpha antibody [MP6-XT3]
  TNF alpha 一次抗体 製品一覧
• 製品の詳細
  Rat Monoclonal [MP6-XT3] to TNF alpha
• 特異性ab11564 recognises murine TNF alpha. Reactivity with murine TNF Beta has not yet been determined.
• アプリケーション適用あり: WB, Flow Cyt, ELISAmore details
• 種交差性
  交差種: Mouse, Rat
  
• 免疫原

  Recombinant full length protein corresponding to Mouse TNF alpha. Expressed in E. coli.
  Database link: P06804

• 特記事項This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use.

製品の特性

• 製品の状態Liquid
• 保存方法Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• バッファーPreservative: 0.09% Sodium Azide
  Constituents: PBS, pH 7.4
• Concentration information loading...
• 精製度Protein G purified
• 特記事項（精製）Purified IgG prepared by affinity chromatography from tissue culture supernatant.
• ポリ/モノモノクローナル
• クローン名MP6-XT3
• アイソタイプIgG1
• 研究分野
  • Immunology
  • Innate Immunity
  • Cytokines
  • TNF Superfamily

  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Cancer
  • Growth factors
  • TNF

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Inflammatory mediators

  • Metabolism
  • Types of disease
  • Metabolic disorders

関連製品

• Affibody® Molecule
  • Anti-TNF alpha Affibody® Molecule (ab31908)
  • Anti-TNF alpha Affibody® Molecule (Agarose) (ab31909)
• Compatible Secondaries
  • Goat Anti-Rat IgG H&L (Alexa Fluor® 488) (ab150157)
  • Goat Anti-Rat IgG H&L (HRP) (ab205720)

アプリケーション

ターゲット情報

• 機能Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
• 関連疾患Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
• 配列類似性Belongs to the tumor necrosis factor family.
• 翻訳後修飾The soluble form derives from the membrane form by proteolytic processing.
  The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
  O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
• 細胞内局在Secreted and Cell membrane.

• Target information above from: UniProt accession P01375 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 参照データベース
  • Entrez Gene: 21926 Mouse
  • Entrez Gene: 24835 Rat
  • SwissProt: P06804 Mouse
  • SwissProt: P16599 Rat
  • Unigene: 1293 Mouse
  • Unigene: 2275 Rat
• 別名
  • APC1 antibody
  • APC1 protein antibody
  • Cachectin antibody

  • DIF antibody
  • Differentiation inducing factor antibody
  • Macrophage cytotoxic factor antibody
  • Tnf antibody
  • TNF superfamily, member 2 antibody
  • TNF, macrophage derived antibody
  • TNF, monocyte derived antibody
  • TNF-a antibody
  • TNF-alpha antibody
  • TNFA antibody
  • TNFA_HUMAN antibody
  • TNFSF2 antibody
  • Tumor necrosis factor alpha antibody
  • Tumor necrosis factor antibody
  • Tumor necrosis factor ligand superfamily member 2 antibody
  • Tumor Necrosis Factor, Membrane Form antibody
  • Tumor necrosis factor, soluble form antibody

  see all