製品の概要

製品の詳細

  • 由来
    Synthetic

特性

Our Abpromise guarantee covers the use of ab8395 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • アプリケーション

    Blocking

  • 製品の状態
    Liquid
  • Concentration information loading...

前処理および保存

  • 保存方法および安定性

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

関連情報

  • 別名
    • Apoptosis associated speck like protein containing a CARD
    • Apoptosis-associated speck-like protein containing a CARD
    • ASC
    • ASC_HUMAN
    • CARD 5
    • CARD5
    • Caspase recruitment domain containing protein 5
    • Caspase recruitment domain protein 5
    • Caspase recruitment domain-containing protein 5
    • hASC
    • MGC10332
    • PYCARD
    • PYD and CARD domain containing
    • PYD and CARD domain containing protein
    • PYD and CARD domain-containing protein
    • Target of methylation induced silencing 1
    • Target of methylation-induced silencing 1
    • TMS
    • TMS 1
    • TMS1
    see all
  • 機能
    Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 組織特異性
    Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.
  • 配列類似性
    Contains 1 CARD domain.
    Contains 1 DAPIN domain.
  • ドメイン
    Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.
  • 翻訳後修飾
    Phosphorylated.
  • 細胞内局在
    Cytoplasm. Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
  • Information by UniProt

参考文献

ab8395 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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