製品の概要

  • 製品名TMPyP4 tosylate
  • 製品の詳細
    Telomerase inhibitor. Binds and stabilizes DNA G-quadruplexes.
  • 生理活性の詳細Cationic porphyrin. Telomerase inhibitor (IC50 = 6.5 µM). Binds and stabilizes DNA G quadruplexes resulting in telomerase inhibition. Displays antitumor effect.
  • 精製度> 94%

製品の特性

    アプリケーション

    Our Abpromise guarantee covers the use of ab120793 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    アプリケーション Abreviews 特記事項
    Functional Studies Use at an assay dependent concentration.

    TMPyP4 tosylate 画像

    • ab2893 staining ?H2A.X in weri cells treated with TMPyP4 tosylate (ab120793), by ICC/IF. Increase of ?H2A.X nuclear expression correlates with increased concentration of TMPyP4 tosylate, as described in literature.
      The cells were incubated at 37°C for 24 hours in media containing different concentrations of ab120793 (TMPyP4 tosylate ) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab2893 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.

    TMPyP4 tosylate (ab120793) 使用論文

    This product has been referenced in:
    • Mikami-Terao Y  et al. Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines. Exp Eye Res 89:200-8 (2009). Read more (PubMed: 19328784) »
    • Kim MY  et al. The different biological effects of telomestatin and TMPyP4 can be attributed to their selectivity for interaction with intramolecular or intermolecular G-quadruplex structures. Cancer Res 63:3247-56 (2003). Read more (PubMed: 12810655) »
    • Shi DF  et al. Quadruplex-interactive agents as telomerase inhibitors: synthesis of porphyrins and structure-activity relationship for the inhibition of telomerase. J Med Chem 44:4509-23 (2001). Read more (PubMed: 11741471) »

    See 0 Publications for this product

    Product Wall

    Thank you for your inquiry.

    I've been checking with the lab and the TMPyP4 tosylate (ab120793) can be dissolved in either water or DMSO. However do not mix both to perform your dilution.

    The test performed in our lab was based on ...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"