製品の概要

  • 製品名Anti-TMEM127 antibody
    TMEM127 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TMEM127
  • アプリケーション適用あり: WB, IPmore details
  • 種交差性
    交差種: Mouse, Human
    交差が予測される動物種: Rat, Rabbit, Guinea pig, Cow, Dog, Pig, Chimpanzee, Ferret, Rhesus monkey, Orangutan
  • 免疫原

    Synthetic peptide corresponding to a region within amino acids 1-50 of Human TMEM127 (NP_060319.1)

  • ポジティブ・コントロール
    • HeLa, 293T, Jurkat, NIH3T3 whole cell lysates

製品の特性

  • 製品の状態Liquid
  • 保存方法Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • バッファーPreservative: 0.09% Sodium azide
    Constituent: 99% Tris citrate/phosphate
    Note: pH: 7-8
  • Concentration information loading...
  • 精製度Immunogen affinity purified
  • ポリ/モノポリクローナル
  • アイソタイプIgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab123516 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/2000 - 1/10000. Predicted molecular weight: 26 kDa.
IP Use at 2-10 µg/mg of lysate.

ターゲット情報

  • 機能Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
  • 組織特異性Widely expressed.
  • 関連疾患Defects in TMEM127 are a cause of susceptibility to pheochromocytoma (PCC) [MIM:171300]. A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
  • 配列類似性Belongs to the TMEM127 family.
  • 細胞内局在Cell membrane. Cytoplasm. Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ20507 antibody
    • FLJ22257 antibody
    • TM127_HUMAN antibody
    • Tmem127 antibody
    • Transmembrane protein 127 antibody
    see all

Anti-TMEM127 antibody 画像

  • All lanes : Anti-TMEM127 antibody (ab123516) at 0.1 µg/ml

    Lane 1 : HeLa whole cell lysate at 50 µg
    Lane 2 : HeLa whole cell lysate at 15 µg
    Lane 3 : 293T whole cell lysate at 50 µg
    Lane 4 : Jurkat whole cell lysate at 50 µg
    Lane 5 : NIH3T3 whole cell lysate at 50 µg

    Developed using the ECL technique

    Predicted band size : 26 kDa


    Exposure time : 3 minutes
  • Detection of TMEM127 by Western Blot of Immunprecipitate.
    Lane 1: ab123516 at 1µg/ml staining TMEM127 in HeLa whole cell lysate immunoprecipitated using ab123516 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
    Lane 2: Control IgG
    Detection: Chemiluminescence with exposure time of 30 seconds.

Anti-TMEM127 antibody (ab123516) 使用論文

ab123516 has not yet been referenced specifically in any publications.

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