製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to TLR8
  • アプリケーション
    適用あり: WB, ICC, IHC-Pmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide:

    CESFQGLQNLTKINLNHNPNVQHQNGNPGI

    , corresponding to amino acids 81-109 of Human TLR8

  • ポジティブ・コントロール
    • Mouse spleen and human tonsil tissue.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53630 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/1000. Predicted molecular weight: 119 kDa.
ICC 1/400. Acetone fixed.
IHC-P Use at an assay dependent dilution.

ターゲット情報

  • 機能
    Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 組織特異性
    Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells.
  • 配列類似性
    Belongs to the Toll-like receptor family.
    Contains 23 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD 288 antibody
    • CD288 antibody
    • CD288 antigen antibody
    • MGC119599 antibody
    • MGC119600 antibody
    • TLR 8 antibody
    • Tlr8 antibody
    • TLR8_HUMAN antibody
    • Toll like receptor 8 antibody
    • Toll-like receptor 8 antibody
    see all

画像

  • ab53630 at 1/250 dilution staining TLR8 in mouse spleen by Immunohistochemistry, Paraffin embedded tissue.
  • ab53630 at 1/250 dilution staining TLR8 in human tonsil by Immunohistochemistry, Paraffin embedded tissue.

参考文献

This product has been referenced in:
  • Jiang C  et al. The Expression of Toll-like receptors in eutopic and ectopic endometrium and its implication in the inflammatory pathogenesis of adenomyosis. Sci Rep 7:7365 (2017). Read more (PubMed: 28779087) »
  • Thiyagarajan D  et al. Silencing of Renal DNaseI in Murine Lupus Nephritis Imposes Exposure of Large Chromatin Fragments and Activation of Toll Like Receptors and the Clec4e. PLoS One 7:e34080 (2012). Read more (PubMed: 22479529) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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