製品の概要

  • 製品名Anti-TLR7 antibody (Phycoerythrin)
    TLR7 一次抗体 製品一覧
  • 製品の詳細
    Rabbit polyclonal to TLR7 (Phycoerythrin)
  • 標識Phycoerythrin. Ex: 488nm, Em: 575nm
  • アプリケーション適用あり: Flow Cytmore details
  • 種交差性
    交差種: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to a region between residues 650-700 of human TLR7, conjugated to KLH.

  • ポジティブ・コントロール
    • Human PBMCs.

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab72331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt Use 0.5-1µg for 106 cells. ab37409-Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 組織特異性Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.
  • 配列類似性Belongs to the Toll-like receptor family.
    Contains 27 LRR (leucine-rich) repeats.
    Contains 1 TIR domain.
  • 細胞内局在Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
  • Information by UniProt
  • 参照データベース
  • 別名
    • PRO285 antibody
    • TLR 7 antibody
    • Tlr7 antibody
    • TLR7_HUMAN antibody
    • Toll like receptor 7 antibody
    • Toll-like receptor 7 antibody
    • UNQ248 antibody
    see all

Anti-TLR7 antibody (Phycoerythrin) 画像

  • ab72331 at 5µg/106 cells staining TLR7 in human PBMCs by flow cytometry (shown in red). Shaded histogram represents PE-conjugated rabbit IgG isotype control.

Anti-TLR7 antibody (Phycoerythrin) (ab72331) 使用論文

This product has been referenced in:
  • Pritchard AL  et al. Asthma is associated with multiple alterations in anti-viral innate signalling pathways. PLoS One 9:e106501 (2014). Flow Cyt ; Human . Read more (PubMed: 25203745) »

See 1 Publication for this product

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I am sorry that you have been having problems with ab72331 in flow cytometry, I have attached the protocol that was used to test this antibody in flow cytometry. I was wondering if this was similar to the proto...

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Vielen Dank für Ihre Anfrage.
Ich schlage vor die optimale Verdünnung für ab72331 zuerst zu testen und dann die Isotyp- Kontrolle (ab37407) in derselben Konzentration einzusetzen.
Die Konzentration von ab37407 ist Lot abhängig. Liegt aber mei...

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Thank you for contacting Abcam Technical Team and for taking the time to provide some useful details of the experiments. I am very sorry to hear that your customer is having problems with this product. I could offer a new vial as a free of charge...

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