Anti-TLR7 抗体 (ab113524)
Key features and details
- Rabbit polyclonal to TLR7
- Suitable for: WB, IHC-P
- Reacts with: Human, Chimpanzee, Monkey
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-TLR7 antibody
TLR7 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to TLR7 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human, Chimpanzee, Monkey
交差が予測される動物種: Mouse, Rat, Horse, Cow, Dog -
免疫原
Synthetic peptide corresponding to a region within amino acids 900-950 of Human TLR7, conjugated to KLH.
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ポジティブ・コントロール
- Human lung and placenta tissues; Ramos cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.05% BSA -
Concentration information loading...
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精製度
Protein G purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab113524の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 121 kDa.
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IHC-P | (1) |
Use a concentration of 10 µg/ml.
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特記事項 |
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WB
Use a concentration of 0.5 - 2 µg/ml. Predicted molecular weight: 121 kDa. |
IHC-P
Use a concentration of 10 µg/ml. |
ターゲット情報
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機能
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. -
組織特異性
Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. -
配列類似性
Belongs to the Toll-like receptor family.
Contains 27 LRR (leucine-rich) repeats.
Contains 1 TIR domain. -
細胞内局在
Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. - Information by UniProt
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参照データベース
- Entrez Gene: 473521 Chimpanzee
- Entrez Gene: 493686 Cow
- Entrez Gene: 491743 Dog
- Entrez Gene: 791248 Horse
- Entrez Gene: 51284 Human
- Entrez Gene: 574291 Monkey
- Entrez Gene: 170743 Mouse
- Entrez Gene: 317468 Rat
see all -
別名
- PRO285 antibody
- TLR 7 antibody
- Tlr7 antibody
see all
画像
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All lanes : Anti-TLR7 antibody (ab113524) at 1 µg/ml
Lane 1 : Ramos cell lysate
Lane 2 : Ramos cell lysate with immunizing peptide
Predicted band size: 121 kDa -
ab113524, at 10 µg/ml, staining TLR7 in formalin fixed, paraffin embedded Human lung tissue by immunohistochemistry.
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ab113524, at 10 µg/ml, staining TLR7 in formalin fixed, paraffin embedded Human placenta tissue by immunohistochemistry.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (2)
ab113524 は 2 報の論文で使用されています。
- Zhu Y et al. Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis. EMBO Mol Med 14:e14455 (2022). PubMed: 34936223
- Feng Y et al. Role of Toll-like receptors in diabetic renal lesions in a miniature pig model. Sci Adv 1:e1400183 (2015). PubMed: 26601192