製品の概要

  • 製品名
  • 製品の詳細
    Goat polyclonal to TLR5
  • 特異性
    Peptide sequence is < 50 % identical to other human TLR receptors in this region.
  • アプリケーション
    適用あり: WB, ELISA, ICC, IHC-Pmore details
  • 種交差性
    交差種: Human
  • 免疫原

    Synthetic peptide:

    DLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQ

    , corresponding to amino acids 151-181 of Human TLR5.

  • ポジティブ・コントロール
    • Human spleen sections or human peripheral blood.
  • 特記事項


    Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.

製品の特性

  • 製品の状態
    Liquid
  • 保存方法
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • バッファー
    PBS, 1mg/ml BSA, 0.1% sodium azide, pH7.2
  • Concentration information loading...
  • 精製度
    Immunogen affinity purified
  • 一次抗体 備考
    Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.
  • ポリ/モノ
    ポリクローナル
  • アイソタイプ
    IgG
  • 研究分野

アプリケーション

Our Abpromise guarantee covers the use of ab1654 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB 1/100.
ELISA 1/75000.
ICC 1/500.
IHC-P 1/250.

ターゲット情報

  • 機能
    Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 組織特異性
    Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.
  • 関連疾患
    Systemic lupus erythematosus 1
  • 配列類似性
    Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • 翻訳後修飾
    Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines.
    Phosphorylated at Tyr-798 upon flagellin binding; required for signaling.
  • 細胞内局在
    Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • FLJ10052 antibody
    • MGC126430 antibody
    • MGC126431 antibody
    • SLEB1 antibody
    • TIL 3 antibody
    • TIL3 antibody
    • TLR 5 antibody
    • Tlr5 antibody
    • TLR5_HUMAN antibody
    • Toll like receptor 5 antibody
    • Toll like receptor 5 precursor antibody
    • Toll-like receptor 5 antibody
    • Toll/interleukin 1 receptor like protein 3 antibody
    • Toll/interleukin-1 receptor-like protein 3 antibody
    see all

画像

  • Immunohistochemistry with ab1654 on paraffin section of human spleen

参考文献

This product has been referenced in:
  • Sipos F  et al. Peripheral blood based discrimination of ulcerative colitis and Crohn's disease from non-IBD colitis by genome-wide gene expression profiling. Dis Markers 30:1-17 (2011). Read more (PubMed: 21508504) »
  • Kim WY  et al. Increased expression of Toll-like receptor 5 during progression of cervical neoplasia. Int J Gynecol Cancer 18:300-5 (2008). Read more (PubMed: 17587322) »

See all 3 Publications for this product

レビューと Q&A

Thank you for your email. Ab1654 is only available in the form indicated on the online datasheet - PBS, 1mg/ml BSA, 0.1% sodium azide, pH 7.2 - and we can't provide it sodium azide free. If you have any additional questions please contact us again.

We do not have any information about the suitability of this antibody for use in blocking studies.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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