Anti-TLR4 抗体 [HTA125] (Biotin) (ab17232)


  • 製品名Anti-TLR4 antibody [HTA125] (Biotin)
    TLR4 一次抗体 製品一覧
  • 製品の詳細
    Mouse monoclonal [HTA125] to TLR4 (Biotin)
  • 標識Biotin
  • アプリケーション適用あり: Flow Cyt, IHC-Frmore details
  • 種交差性
    交差種: Human, Cynomolgus monkey, Rhesus monkey
  • 免疫原

    TLR4 expressing Ba/F3 cells.

  • ポジティブ・コントロール
    • Human peripheral blood monocytes
  • 特記事項

    Ab17232 reacts preferentially, especially in flow cytometry, with human TLR4 associated with MD-2. It is a LR4 function blocking antibody that is useful for studies on the role of TR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells.



Our Abpromise guarantee covers the use of ab17232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
Flow Cyt 1/50. ab18454-Mouse monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
IHC-Fr 1/50.


  • 機能Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
  • 組織特異性Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.
  • 関連疾患Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:611488]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
  • 配列類似性Belongs to the Toll-like receptor family.
    Contains 18 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 TIR domain.
  • ドメインThe TIR domain mediates interaction with NOX4.
  • 翻訳後修飾N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
  • 細胞内局在Membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • ARMD10 antibody
    • CD284 antibody
    • CD284 antigen antibody
    • Homolog of Drosophila toll antibody
    • hToll antibody
    • TLR 4 antibody
    • TLR4 antibody
    • TLR4_HUMAN antibody
    • TOLL antibody
    • Toll like receptor 4 antibody
    • Toll-like receptor 4 antibody
    see all

Anti-TLR4 antibody [HTA125] (Biotin) (ab17232) 使用論文

ab17232 has not yet been referenced specifically in any publications.

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Thank you for your enquiry. Unfortunately I have not been able to obtain a specific protocol for this antiserum. However, we do have an excellent IHC-Fr protocol located at the following link:

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Thank you for your enquiry. Yes, ab17232 has been tested for application in IHC-frozen sections and tested for cross-reactivity with Human, Cynomolgus Monkey, Marmoset Monkey and Rhesus monkey. I would suggest a dilution range of 1:20-1:200, and optimi...

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