製品の概要

製品の特性

アプリケーション

Our Abpromise guarantee covers the use of ab53424 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

アプリケーション Abreviews 特記事項
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 104 kDa (predicted molecular weight: 104 kDa).
IHC-P Use at an assay dependent concentration.

ターゲット情報

  • 機能Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
  • 組織特異性Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
  • 関連疾患Defects in TLR3 are associated with herpes simplex encephalitis type 2 (HSE2) [MIM:613002]. HSE is a rare complication of human herpesvirus 1 (HHV-1) infection, occurring in only a small minority of HHV-1 infected individuals. HSE is characterized by hemorrhagic necrosis of parts of the temporal and frontal lobes. Onset is over several days and involves fever, headache, seizures, stupor, and often coma, frequently with a fatal outcome. Note=TLR3 mutations predispose otherwise healthy individuals to isolated herpes simplex encephalitis through a mechanism that involves impaired IFNs production and reduced immune defense against viral infection in the central nervous system.
  • 配列類似性Belongs to the Toll-like receptor family.
    Contains 22 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
    Contains 1 TIR domain.
  • ドメインds-RNA binding is mediated by LRR 1 to 3, and LRR 17 to 18.
  • 翻訳後修飾Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding.
  • 細胞内局在Endoplasmic reticulum membrane. Endosome membrane.
  • Information by UniProt
  • 参照データベース
  • 別名
    • CD283 antibody
    • CD283 antigen antibody
    • IIAE2 antibody
    • TLR 3 antibody
    • Tlr3 antibody
    • TLR3_HUMAN antibody
    • Toll Like Receptor 3 antibody
    • Toll-like receptor 3 antibody
    see all

Anti-TLR3 antibody 画像

  • Anti-TLR3 antibody (ab53424) at 3 µg/ml + mouse spleen tissue lysate at 15 µg

    Predicted band size : 104 kDa
    Observed band size : 104 kDa

Anti-TLR3 antibody (ab53424) 使用論文

ab53424 has not yet been referenced specifically in any publications.

Product Wall

Amino acids 727 to 905 are cytoplasmic according to the Features map of the protein at the bottom of this page: http://www.expasy.org/cgi-bin/niceprot.pl?Q99MB1 Two of the peptides this polyclonal is raised against are found in this domain: 828...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"